Sex differences in csf biomarkers for neurodegeneration and blood-brain barrier integrity

Tobias Skillbäck; Kaj Blennow; Henrik Zetterberg; Sara Shams; Alejandra Machado; Joana Pereira; Olof Lindberg; Michelle M. Mielke; Anna Zettergren; Lina Ryden; Eric Westman; Lars Olof Wahlund; Ingmar Skoog; Silke Kern

doi:10.1002/dad2.12141

Sex differences in csf biomarkers for neurodegeneration and blood-brain barrier integrity

Tobias Skillbäck, Kaj Blennow, Henrik Zetterberg, Sara Shams, Alejandra Machado, Joana Pereira, Olof Lindberg, Michelle M. Mielke, Anna Zettergren, Lina Ryden, Eric Westman, Lars Olof Wahlund, Ingmar Skoog, Silke Kern

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (Q_Alb ) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand. Methods: Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, Q_Alb, n = 39252, age 0 to 95). In the population-based study, Q_Alb and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, Q_Alb and NfL sex differences were tested in relation to age. Results: Men had higher Q_Alb and NfL concentrations and had higher Q_Alb and NfL concentrations from adolescence throughout life. NfL was not related to WML, but Q_Alb correlated positively with WMLs. Discussion: The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.

Original language	English (US)
Article number	e12141
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12141
State	Published - 2021

Keywords

Albumin ratio
Blood-brain barrier integrity
CSF biomarkers
Neurofilament light
Sex differences

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

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10.1002/dad2.12141

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Skillbäck, T., Blennow, K., Zetterberg, H., Shams, S., Machado, A., Pereira, J., Lindberg, O., Mielke, M. M., Zettergren, A., Ryden, L., Westman, E., Wahlund, L. O., Skoog, I., & Kern, S. (2021). Sex differences in csf biomarkers for neurodegeneration and blood-brain barrier integrity. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12141. https://doi.org/10.1002/dad2.12141

Skillbäck, T, Blennow, K, Zetterberg, H, Shams, S, Machado, A, Pereira, J, Lindberg, O, Mielke, MM, Zettergren, A, Ryden, L, Westman, E, Wahlund, LO, Skoog, I & Kern, S 2021, 'Sex differences in csf biomarkers for neurodegeneration and blood-brain barrier integrity', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 13, no. 1, e12141. https://doi.org/10.1002/dad2.12141

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abstract = "Introduction: As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (QAlb ) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand. Methods: Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, QAlb, n = 39252, age 0 to 95). In the population-based study, QAlb and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, QAlb and NfL sex differences were tested in relation to age. Results: Men had higher QAlb and NfL concentrations and had higher QAlb and NfL concentrations from adolescence throughout life. NfL was not related to WML, but QAlb correlated positively with WMLs. Discussion: The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.",

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author = "Tobias Skillb{\"a}ck and Kaj Blennow and Henrik Zetterberg and Sara Shams and Alejandra Machado and Joana Pereira and Olof Lindberg and Mielke, {Michelle M.} and Anna Zettergren and Lina Ryden and Eric Westman and Wahlund, {Lars Olof} and Ingmar Skoog and Silke Kern",

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year = "2021",

doi = "10.1002/dad2.12141",

language = "English (US)",

volume = "13",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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AU - Skillbäck, Tobias

AU - Blennow, Kaj

AU - Zetterberg, Henrik

AU - Shams, Sara

AU - Machado, Alejandra

AU - Pereira, Joana

AU - Lindberg, Olof

AU - Mielke, Michelle M.

AU - Zettergren, Anna

AU - Ryden, Lina

AU - Westman, Eric

AU - Wahlund, Lars Olof

AU - Skoog, Ingmar

AU - Kern, Silke

PY - 2021

Y1 - 2021

N2 - Introduction: As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (QAlb ) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand. Methods: Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, QAlb, n = 39252, age 0 to 95). In the population-based study, QAlb and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, QAlb and NfL sex differences were tested in relation to age. Results: Men had higher QAlb and NfL concentrations and had higher QAlb and NfL concentrations from adolescence throughout life. NfL was not related to WML, but QAlb correlated positively with WMLs. Discussion: The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.

AB - Introduction: As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (QAlb ) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand. Methods: Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, QAlb, n = 39252, age 0 to 95). In the population-based study, QAlb and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, QAlb and NfL sex differences were tested in relation to age. Results: Men had higher QAlb and NfL concentrations and had higher QAlb and NfL concentrations from adolescence throughout life. NfL was not related to WML, but QAlb correlated positively with WMLs. Discussion: The CSF NfL sex difference could not be explained by vascular pathology. Future studies should consider using different reference limits for men and women.

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KW - Neurofilament light

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Sex differences in csf biomarkers for neurodegeneration and blood-brain barrier integrity

Abstract

Keywords

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