Sex Differences in Autonomic Function

Emma C. Hart, Nisha Charkoudian, Michael Joseph Joyner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

This chapter focuses on sex differences in autonomic function and orthostatic intolerance and hypotension. In humans, both normal and pathophysiological mechanisms of autonomic control of blood pressure are modified by sex. Tonic sympathetic nerve activity can be measured using microneurography to measure muscle sympathetic nerve activity (MSNA) or norepinephrine spill-over techniques. Central estrogen administration also increases resting vagal tone in female mice, suggesting the sex hormones might also influence parasympathetic outflow to the heart. It is well accepted that even healthy young women who do not have symptoms of POTS are predisposed to orthostatic intolerance or hypotension at a greater rate compared to men. The exact mechanisms underlying this predisposition are unclear. The sympathetic nerve system is involved in the pathogenesis of hypertension, with many studies demonstrating that sympathetic nerve activity is elevated among individuals with hypertension. Aging is associated with an increased risk of developing hypertension. In this context, aging is associated with a gradual augmentation in sympathetic nerve activity and arterial pressure.

Original languageEnglish (US)
Title of host publicationPrimer on the Autonomic Nervous System
PublisherElsevier Inc.
Pages261-264
Number of pages4
ISBN (Print)9780123865250
DOIs
StatePublished - 2012

Fingerprint

Orthostatic Intolerance
Sex Characteristics
Orthostatic Hypotension
Hypertension
Gonadal Steroid Hormones
Norepinephrine
Arterial Pressure
Estrogens
Blood Pressure
Muscles

Keywords

  • Adrenergic
  • Aging
  • Blood pressure
  • Sympathetic nerve activity
  • Vasoconstriction
  • Vasodilation
  • Women

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hart, E. C., Charkoudian, N., & Joyner, M. J. (2012). Sex Differences in Autonomic Function. In Primer on the Autonomic Nervous System (pp. 261-264). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-386525-0.00054-8

Sex Differences in Autonomic Function. / Hart, Emma C.; Charkoudian, Nisha; Joyner, Michael Joseph.

Primer on the Autonomic Nervous System. Elsevier Inc., 2012. p. 261-264.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hart, EC, Charkoudian, N & Joyner, MJ 2012, Sex Differences in Autonomic Function. in Primer on the Autonomic Nervous System. Elsevier Inc., pp. 261-264. https://doi.org/10.1016/B978-0-12-386525-0.00054-8
Hart EC, Charkoudian N, Joyner MJ. Sex Differences in Autonomic Function. In Primer on the Autonomic Nervous System. Elsevier Inc. 2012. p. 261-264 https://doi.org/10.1016/B978-0-12-386525-0.00054-8
Hart, Emma C. ; Charkoudian, Nisha ; Joyner, Michael Joseph. / Sex Differences in Autonomic Function. Primer on the Autonomic Nervous System. Elsevier Inc., 2012. pp. 261-264
@inbook{88c381ccfc4c49e09daeffa29d089245,
title = "Sex Differences in Autonomic Function",
abstract = "This chapter focuses on sex differences in autonomic function and orthostatic intolerance and hypotension. In humans, both normal and pathophysiological mechanisms of autonomic control of blood pressure are modified by sex. Tonic sympathetic nerve activity can be measured using microneurography to measure muscle sympathetic nerve activity (MSNA) or norepinephrine spill-over techniques. Central estrogen administration also increases resting vagal tone in female mice, suggesting the sex hormones might also influence parasympathetic outflow to the heart. It is well accepted that even healthy young women who do not have symptoms of POTS are predisposed to orthostatic intolerance or hypotension at a greater rate compared to men. The exact mechanisms underlying this predisposition are unclear. The sympathetic nerve system is involved in the pathogenesis of hypertension, with many studies demonstrating that sympathetic nerve activity is elevated among individuals with hypertension. Aging is associated with an increased risk of developing hypertension. In this context, aging is associated with a gradual augmentation in sympathetic nerve activity and arterial pressure.",
keywords = "Adrenergic, Aging, Blood pressure, Sympathetic nerve activity, Vasoconstriction, Vasodilation, Women",
author = "Hart, {Emma C.} and Nisha Charkoudian and Joyner, {Michael Joseph}",
year = "2012",
doi = "10.1016/B978-0-12-386525-0.00054-8",
language = "English (US)",
isbn = "9780123865250",
pages = "261--264",
booktitle = "Primer on the Autonomic Nervous System",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Sex Differences in Autonomic Function

AU - Hart, Emma C.

AU - Charkoudian, Nisha

AU - Joyner, Michael Joseph

PY - 2012

Y1 - 2012

N2 - This chapter focuses on sex differences in autonomic function and orthostatic intolerance and hypotension. In humans, both normal and pathophysiological mechanisms of autonomic control of blood pressure are modified by sex. Tonic sympathetic nerve activity can be measured using microneurography to measure muscle sympathetic nerve activity (MSNA) or norepinephrine spill-over techniques. Central estrogen administration also increases resting vagal tone in female mice, suggesting the sex hormones might also influence parasympathetic outflow to the heart. It is well accepted that even healthy young women who do not have symptoms of POTS are predisposed to orthostatic intolerance or hypotension at a greater rate compared to men. The exact mechanisms underlying this predisposition are unclear. The sympathetic nerve system is involved in the pathogenesis of hypertension, with many studies demonstrating that sympathetic nerve activity is elevated among individuals with hypertension. Aging is associated with an increased risk of developing hypertension. In this context, aging is associated with a gradual augmentation in sympathetic nerve activity and arterial pressure.

AB - This chapter focuses on sex differences in autonomic function and orthostatic intolerance and hypotension. In humans, both normal and pathophysiological mechanisms of autonomic control of blood pressure are modified by sex. Tonic sympathetic nerve activity can be measured using microneurography to measure muscle sympathetic nerve activity (MSNA) or norepinephrine spill-over techniques. Central estrogen administration also increases resting vagal tone in female mice, suggesting the sex hormones might also influence parasympathetic outflow to the heart. It is well accepted that even healthy young women who do not have symptoms of POTS are predisposed to orthostatic intolerance or hypotension at a greater rate compared to men. The exact mechanisms underlying this predisposition are unclear. The sympathetic nerve system is involved in the pathogenesis of hypertension, with many studies demonstrating that sympathetic nerve activity is elevated among individuals with hypertension. Aging is associated with an increased risk of developing hypertension. In this context, aging is associated with a gradual augmentation in sympathetic nerve activity and arterial pressure.

KW - Adrenergic

KW - Aging

KW - Blood pressure

KW - Sympathetic nerve activity

KW - Vasoconstriction

KW - Vasodilation

KW - Women

UR - http://www.scopus.com/inward/record.url?scp=84882821273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882821273&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-386525-0.00054-8

DO - 10.1016/B978-0-12-386525-0.00054-8

M3 - Chapter

AN - SCOPUS:84882821273

SN - 9780123865250

SP - 261

EP - 264

BT - Primer on the Autonomic Nervous System

PB - Elsevier Inc.

ER -