Sex differences in a murine model of Sjögren's syndrome

Daniela Iháková, Monica V. Talor, Jobert G. Barin, G. Christian Baldeviano, Delisa Fairweather, Noel R. Rose, C. Lynne Burek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Scopus citations

Abstract

Sex differences in a NOD.H2h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4+ T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

Original languageEnglish (US)
Title of host publicationContemporary Challenges in Autoimmunity
PublisherBlackwell Publishing Inc.
Pages378-383
Number of pages6
ISBN (Print)9781573317627
DOIs
StatePublished - Sep 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1173
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • BAFF
  • IL-17
  • SSA and SSB antibodies
  • Salivary gland
  • Sex differences
  • Sjögren's syndrome
  • T cells
  • Th17

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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  • Cite this

    Iháková, D., Talor, M. V., Barin, J. G., Baldeviano, G. C., Fairweather, D., Rose, N. R., & Burek, C. L. (2009). Sex differences in a murine model of Sjögren's syndrome. In Contemporary Challenges in Autoimmunity (pp. 378-383). (Annals of the New York Academy of Sciences; Vol. 1173). Blackwell Publishing Inc.. https://doi.org/10.1111/j.1749-6632.2009.04760.x