Sex differences in a murine model of Sjögren's syndrome

Daniela Iháková, Monica V. Talor, Jobert G. Barin, G. Christian Baldeviano, DeLisa Fairweather, Noel R. Rose, C. Lynne Burek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

20 Scopus citations

Abstract

Sex differences in a NOD.H2 h4 murine model of Sjögren's syndrome were analyzed. Compared to males, female NOD.H2 h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4 + T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sjögren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.

Original languageEnglish (US)
Title of host publicationContemporary Challenges in Autoimmunity
Pages378-383
Number of pages6
Volume1173
DOIs
StatePublished - Sep 2009
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1173
ISSN (Print)00778923
ISSN (Electronic)17496632

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Keywords

  • BAFF
  • IL-17
  • NOD.H2 mouse
  • Salivary gland
  • Sex differences
  • Sjögren's syndrome
  • SSA and SSB antibodies
  • T cells
  • Th17

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Iháková, D., Talor, M. V., Barin, J. G., Baldeviano, G. C., Fairweather, D., Rose, N. R., & Burek, C. L. (2009). Sex differences in a murine model of Sjögren's syndrome. In Contemporary Challenges in Autoimmunity (Vol. 1173, pp. 378-383). (Annals of the New York Academy of Sciences; Vol. 1173). https://doi.org/10.1111/j.1749-6632.2009.04760.x