@inproceedings{b520142d2a794b6eb4ccf86a7fbeccbf,
title = "Sex differences in a murine model of Sj{\"o}gren's syndrome",
abstract = "Sex differences in a NOD.H2h4 murine model of Sj{\"o}gren's syndrome were analyzed. Compared to males, female NOD.H2h4 mice have increased severity of sialoadenitis and have a significantly increased percentage of CD4+ T cells in salivary gland infiltrates. CD4 + T cells in female infiltrates produce more Th2 and Th17 cytokines than in males, while males have greater Th1 responses. Females also have enhanced B cell responses, with higher levels of SSA and SSB serum antibodies, and B cell activation factor F (BAFF). Thus, sex has a strong impact on the severity of murine Sj{\"o}gren's syndrome by affecting the immune mechanisms driving the autoimmune inflammation.",
keywords = "BAFF, IL-17, SSA and SSB antibodies, Salivary gland, Sex differences, Sj{\"o}gren's syndrome, T cells, Th17",
author = "Daniela Ih{\'a}kov{\'a} and Talor, {Monica V.} and Barin, {Jobert G.} and Baldeviano, {G. Christian} and Delisa Fairweather and Rose, {Noel R.} and Burek, {C. Lynne}",
year = "2009",
month = sep,
doi = "10.1111/j.1749-6632.2009.04760.x",
language = "English (US)",
isbn = "9781573317627",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "378--383",
booktitle = "Contemporary Challenges in Autoimmunity",
}