TY - JOUR
T1 - Sex-dependent impact of OSA on digital vascular function
AU - Randby, Anna
AU - Namtvedt, Silje K.
AU - Hrubos-Strøm, Harald
AU - Einvik, Gunnar
AU - Somers, Virend K.
AU - Omland, Torbjørn
N1 - Funding Information:
Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Omland has received research grant support from Abbott Laboratories and speaker's honoraria from Roche Diagnostics, Abbott Laboratories, and Siemens Healthcare Diagnostics. Dr Somers has served as a consultant for Johnson & Johnson; Medtronic, Inc; ResMed; Philips Respironics; Apnex Medical, Inc; NeuPro; Deshum Medical; and Sova Pharmaceuticals, Inc. He has received research grants from the Respironics Charitable Foundation and the National Institutes Health. Drs Randby, Namtvedt, Hrubos-Strøm, and Einvik have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
PY - 2013/9
Y1 - 2013/9
N2 - Background: Indexes of associations between OSA and impaired vascular function are mainly based on small, clinic-based studies of conduit artery function in men with severe sleep apnea. Larger population-based studies show no independent associations or associations in women only. Sex differences in OSA-related mortality may exist, and sex differences in vascular function in subjects with OSA need to be explored. We, therefore, assessed whether OSA is associated with digital vascular function in a large population-based sample and whether this association is infl uenced by sex. Methods: From a population-based cohort of 30,000 subjects aged 30 to 65 years, we examined 479 subjects (mean age, 48 years; 43% women). Oversampling of subjects at high risk of OSA was performed. Sleep apnea was assessed by inhospital polysomnography. Endothelial function was assessed by digital peripheral arterial tonometry and was expressed as the reactive hyperemia index (RHI). Results: OSA was diagnosed in 266 subjects (55.5%). The RHI was signifi cantly lower in subjects with severe OSA than in those without OSA (P = .002). In the multivariate model for RHI, a signifi cant interaction between OSA and sex was found. In sex-specifi c multivariate linear regression models, adjusting for conventional cardiovascular risk factors, OSA was an independent predictor of a low RHI in women (P = .006) but not in men. The association between OSA and low RHI in women was independent of postmenopausal status. Conclusions: In a large population-based sample of middle-aged subjects, OSA was independently associated with impaired digital vascular function in women only.
AB - Background: Indexes of associations between OSA and impaired vascular function are mainly based on small, clinic-based studies of conduit artery function in men with severe sleep apnea. Larger population-based studies show no independent associations or associations in women only. Sex differences in OSA-related mortality may exist, and sex differences in vascular function in subjects with OSA need to be explored. We, therefore, assessed whether OSA is associated with digital vascular function in a large population-based sample and whether this association is infl uenced by sex. Methods: From a population-based cohort of 30,000 subjects aged 30 to 65 years, we examined 479 subjects (mean age, 48 years; 43% women). Oversampling of subjects at high risk of OSA was performed. Sleep apnea was assessed by inhospital polysomnography. Endothelial function was assessed by digital peripheral arterial tonometry and was expressed as the reactive hyperemia index (RHI). Results: OSA was diagnosed in 266 subjects (55.5%). The RHI was signifi cantly lower in subjects with severe OSA than in those without OSA (P = .002). In the multivariate model for RHI, a signifi cant interaction between OSA and sex was found. In sex-specifi c multivariate linear regression models, adjusting for conventional cardiovascular risk factors, OSA was an independent predictor of a low RHI in women (P = .006) but not in men. The association between OSA and low RHI in women was independent of postmenopausal status. Conclusions: In a large population-based sample of middle-aged subjects, OSA was independently associated with impaired digital vascular function in women only.
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U2 - 10.1378/chest.12-2283
DO - 10.1378/chest.12-2283
M3 - Article
C2 - 23471187
AN - SCOPUS:84884322951
VL - 144
SP - 915
EP - 922
JO - Diseases of the chest
JF - Diseases of the chest
SN - 0012-3692
IS - 3
ER -