TY - JOUR
T1 - Sex, Cells, and Asthma
AU - Chiarella, Sergio E.
AU - Cardet, Juan Carlos
AU - Prakash, Y. S.
N1 - Publisher Copyright:
© 2021 Mayo Foundation for Medical Education and Research
PY - 2021/7
Y1 - 2021/7
N2 - There are marked sex differences in asthma prevalence and severity. Sex hormones play a central role in these sex biases and directly interact with multiple key cells involved in the pathogenesis of asthma. Here we review the known effects of estrogen, progesterone, and testosterone on airway epithelial cells, airway smooth muscle cells, the mononuclear phagocyte system, innate lymphoid cells, eosinophils, mast cells, T cells, and B cells, all in the context of asthma. Furthermore, we explore unresolved clinical questions, such as the role of sex hormones in the link between asthma and obesity.
AB - There are marked sex differences in asthma prevalence and severity. Sex hormones play a central role in these sex biases and directly interact with multiple key cells involved in the pathogenesis of asthma. Here we review the known effects of estrogen, progesterone, and testosterone on airway epithelial cells, airway smooth muscle cells, the mononuclear phagocyte system, innate lymphoid cells, eosinophils, mast cells, T cells, and B cells, all in the context of asthma. Furthermore, we explore unresolved clinical questions, such as the role of sex hormones in the link between asthma and obesity.
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U2 - 10.1016/j.mayocp.2020.12.007
DO - 10.1016/j.mayocp.2020.12.007
M3 - Review article
C2 - 34218868
AN - SCOPUS:85108856253
SN - 0025-6196
VL - 96
SP - 1955
EP - 1969
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 7
ER -