Sex-based differences in vascular function

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality for both men and women in the USA. However, there are differences between the sexes in age-dependent onset, severity, symptoms and outcomes. Basic research into the causes of sex-dependent differences in cardiovascular disease is ongoing and includes investigation into genetic variation in expression and distribution of receptors for the sex steroids; specificity of natural and synthetic ligands that activate the sex steroid receptors; and intracellular mechanisms that are activated by the receptors in all components of the vessel wall and blood elements, which integrate to regulate vascular tone, vascular repair and remodeling in health and disease. In this era of personalized medicine, basic research into mechanisms of sex differences in vascular function will result in improved prevention, detection and treatment of cardiovascular disease in both men and women.

Original languageEnglish (US)
Pages (from-to)737-752
Number of pages16
JournalWomen's Health
Volume6
Issue number5
DOIs
StatePublished - Sep 2010

Fingerprint

Sex Characteristics
Blood Vessels
Cardiovascular Diseases
Steroid Receptors
Precision Medicine
Sex Distribution
Age of Onset
Research
Ligands
Morbidity
Mortality
Health
Therapeutics
Vascular Remodeling

Keywords

  • cardiovascular disease
  • endothelial cells
  • estrogen
  • genetic polymorphisms
  • Kronos Early Estrogen Prevention study
  • testosterone
  • Womens Health Initiative

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sex-based differences in vascular function. / Miller, Virginia M.

In: Women's Health, Vol. 6, No. 5, 09.2010, p. 737-752.

Research output: Contribution to journalArticle

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