Sex and sex steroids: Impact on the kinetics of fatty acids underlying body shape

Sylvia Santosa, Michael D. Jensen

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Adult humans have a remarkable sexual dimorphism in body shape. Men tend to store relatively more fat in the upper body whereas women store more fat in the lower body. We do not have a complete understanding of the mechanisms underlying these differences, but we know that people who preferentially store abdominal fat are at greater risk of metabolic disease. It is also known that the changes in sex steroid concentrations during puberty and again with advancing age are accompanied by changes in body fat distribution. The objective of this review is to describe what has been learned regarding the mechanisms underlying changes in regional body fat distribution that occur as a result of changes in sex hormones and to delineate effects of sex steroids in modulating body composition.

Original languageEnglish (US)
Pages (from-to)15-23
Number of pages9
JournalHormone Molecular Biology and Clinical Investigation
Volume20
Issue number1
DOIs
StatePublished - Oct 1 2014

Keywords

  • Aging
  • body fat distribution
  • lipid metabolism
  • sex dimorphism
  • sex steroid hormones

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Endocrinology

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