TY - JOUR
T1 - Sex and Gender Differences in Myocarditis and Dilated Cardiomyopathy
AU - Fairweather, De Lisa
AU - Cooper, Leslie T.
AU - Blauwet, Lori A.
N1 - Funding Information:
Dr DeLisa Fairweather thanks the National Institutes of Health ( R01 HL087033 ) for funding support.
PY - 2013/1
Y1 - 2013/1
N2 - Heart failure due to nonischemic dilated cardiomyopathy (DCM) contributes significantly to the global burden of cardiovascular disease. Myocarditis is, in turn, a major cause of acute DCM in both men and women. However, recent clinical and experimental evidence suggests that the pathogenesis and prognosis of DCM differ between the sexes. This seminar provides a contemporary perspective on the immune mediators of myocarditis, including interdependent elements of the innate and adaptive immune response. The heart's acute response to injury is influenced by sex hormones that appear to determine the subsequent risk of chronic DCM. Preliminary data suggest additional genetic variations may account for some of the differences in epidemiology, left ventricular recovery, and survival between men and women. We highlight the gaps in our knowledge regarding the management of women with acute DCM and discuss emerging therapies, including bromocriptine for the treatment of peripartum cardiomyopathy.
AB - Heart failure due to nonischemic dilated cardiomyopathy (DCM) contributes significantly to the global burden of cardiovascular disease. Myocarditis is, in turn, a major cause of acute DCM in both men and women. However, recent clinical and experimental evidence suggests that the pathogenesis and prognosis of DCM differ between the sexes. This seminar provides a contemporary perspective on the immune mediators of myocarditis, including interdependent elements of the innate and adaptive immune response. The heart's acute response to injury is influenced by sex hormones that appear to determine the subsequent risk of chronic DCM. Preliminary data suggest additional genetic variations may account for some of the differences in epidemiology, left ventricular recovery, and survival between men and women. We highlight the gaps in our knowledge regarding the management of women with acute DCM and discuss emerging therapies, including bromocriptine for the treatment of peripartum cardiomyopathy.
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U2 - 10.1016/j.cpcardiol.2012.07.003
DO - 10.1016/j.cpcardiol.2012.07.003
M3 - Article
C2 - 23158412
AN - SCOPUS:84869458989
SN - 0146-2806
VL - 38
SP - 7
EP - 46
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 1
ER -