TY - JOUR
T1 - Severe symptomatic sinus bradycardia associated with mesalamine use
AU - Asirvatham, Sam
AU - Sebastian, Cherian
AU - Thadani, Udho
PY - 1998/3
Y1 - 1998/3
N2 - A 29-yr-old white woman was hospitalized with bloody diarrhea secondary to ulcerative colitis. Within 24 h of receiving intravenous steroids, loperamide, and mesalamine, she developed symptomatic hypotension, severe sinus bradycardia, sinus pauses, and junctional escape beats. The hypotension and sinus bradycardia resolved after discontinuing mesalamine. She had a family history of conduction tissue disease but her exercise ECG and Holter studies were normal. She was rehospitalized 6 wk later with an exacerbation of ulcerative colitis and, within 8 h of receiving mesalamine, developed hypotension and severe sinus bradycardia, which resolved after stopping mesalamine. Thus mesalamine should be used with caution, especially in patients predisposed to cardiac conduction tissue disease.
AB - A 29-yr-old white woman was hospitalized with bloody diarrhea secondary to ulcerative colitis. Within 24 h of receiving intravenous steroids, loperamide, and mesalamine, she developed symptomatic hypotension, severe sinus bradycardia, sinus pauses, and junctional escape beats. The hypotension and sinus bradycardia resolved after discontinuing mesalamine. She had a family history of conduction tissue disease but her exercise ECG and Holter studies were normal. She was rehospitalized 6 wk later with an exacerbation of ulcerative colitis and, within 8 h of receiving mesalamine, developed hypotension and severe sinus bradycardia, which resolved after stopping mesalamine. Thus mesalamine should be used with caution, especially in patients predisposed to cardiac conduction tissue disease.
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U2 - 10.1111/j.1572-0241.1998.468_2.x
DO - 10.1111/j.1572-0241.1998.468_2.x
M3 - Article
C2 - 9517663
AN - SCOPUS:0032034050
SN - 0002-9270
VL - 93
SP - 470
EP - 471
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -