Severe Graft-versus-Host Disease in a Liver-Transplant Recipient

James F. Burdick, Georgia B. Vogelsang, William J. Smith, Evan R. Farmer, Wilma B. Bias, Scott H. Kaufmann, Janet Horn, Paul M. Colombani, Henry A. Pitt, Bruce A. Perler, William T. Merritt, G. Melville Williams, John K. Boitnott, H. Franklin Herlong

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139 Scopus citations

Abstract

CLINICALLY evident generalized graft-versus-host disease is not thought to occur as a consequence of transplantation of most solid organs. The requisite large inoculum of donor lymphoid cells and inability of the recipient to destroy these passenger cells1 are apparently rarely produced by solid-organ transplantation. However, there is a high risk of graft-versus-host disease when normal spleens are included in vascularized pancreas-transplants.2345 We report on a case of severe generalized acute graft-versus-host disease in a recipient of a liver transplant, involving documented transient chimerism of donor origin. This life-threatening complication was treated successfully with increases in the corticosteroid dosage and the.

Original languageEnglish (US)
Pages (from-to)689-691
Number of pages3
JournalNew England Journal of Medicine
Volume318
Issue number11
DOIs
StatePublished - Mar 17 1988

ASJC Scopus subject areas

  • Medicine(all)

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    Burdick, J. F., Vogelsang, G. B., Smith, W. J., Farmer, E. R., Bias, W. B., Kaufmann, S. H., Horn, J., Colombani, P. M., Pitt, H. A., Perler, B. A., Merritt, W. T., Williams, G. M., Boitnott, J. K., & Herlong, H. F. (1988). Severe Graft-versus-Host Disease in a Liver-Transplant Recipient. New England Journal of Medicine, 318(11), 689-691. https://doi.org/10.1056/NEJM198803173181107