Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper

J. Bousquet, J. M. Anto, P. Demoly, H. J. Schünemann, A. Togias, M. Akdis, C. Auffray, C. Bachert, T. Bieber, P. J. Bousquet, K. H. Carlsen, T. B. Casale, A. A. Cruz, T. Keil, K. C. Lodrup Carlsen, M. Maurer, K. Ohta, N. G. Papadopoulos, M. Roman Rodriguez, B. SamolinskiI. Agache, A. Andrianarisoa, C. S. Ang, I. Annesi-Maesano, F. Ballester, C. E. Baena-Cagnani, X. Basagaña, E. D. Bateman, E. H. Bel, A. Bedbrook, B. Beghé, M. Beji, A. Ben Kheder, M. Benet, K. S. Bennoor, K. C. Bergmann, F. Berrissoul, C. Bindslev Jensen, E. R. Bleecker, S. Bonini, A. L. Boner, L. P. Boulet, C. E. Brightling, J. L. Brozek, A. Bush, W. W. Busse, P. A.M. Camargos, G. W. Canonica, W. Carr, A. Cesario, Y. Z. Chen, A. M. Chiriac, D. J. Costa, L. Cox, A. Custovic, R. Dahl, U. Darsow, T. Didi, W. K. Dolen, H. Douagui, R. Dubakiene, A. El-Meziane, J. A. Fonseca, W. J. Fokkens, E. Fthenou, A. Gamkrelidze, J. Garcia-Aymerich, R. Gerth Van Wijk, E. Gimeno-Santos, S. Guerra, T. Haahtela, H. Haddad, P. W. Hellings, B. Hellquist-Dahl, C. Hohmann, P. Howarth, J. O. Hourihane, M. Humbert, B. Jacquemin, J. Just, O. Kalayci, M. A. Kaliner, F. Kauffmann, M. Kerkhof, G. Khayat, B. Koffi N'Goran, M. Kogevinas, G. H. Koppelman, M. L. Kowalski, I. Kull, P. Kuna, D. Larenas, I. Lavi, L. T. Le, P. Lieberman, B. Lipworth, B. Mahboub, M. J. Makela, F. Martin, F. D. Martinez, G. D. Marshall, A. Mazon, E. Melen, E. O. Meltzer, F. Mihaltan, Y. Mohammad, A. Mohammadi, I. Momas, M. Morais-Almeida, J. Mullol, A. Muraro, R. Naclerio, S. Nafti, L. Namazova-Baranova, M. C. Nawijn, T. D. Nyembue, S. Oddie, R. E. O'Hehir, Y. Okamoto, M. P. Orru, C. Ozdemir, G. S. Ouedraogo, S. Palkonen, P. Panzner, G. Passalacqua, R. Pawankar, B. Pigearias, I. Pin, M. Pinart, C. Pison, T. A. Popov, D. Porta, D. S. Postma, D. Price, K. F. Rabe, J. Ratomaharo, S. Reitamo, D. Rezagui, J. Ring, R. Roberts, J. Roca, B. Rogala, A. Romano, J. Rosado-Pinto, D. Ryan, M. Sanchez-Borges, G. K. Scadding, A. Sheikh, F. E.R. Simons, V. Siroux, P. D. Schmid-Grendelmeier, H. A. Smit, T. Sooronbaev, R. T. Stein, P. J. Sterk, J. Sunyer, I. Terreehorst, E. Toskala, Y. Tremblay, R. Valenta, D. Valeyre, O. Vandenplas, C. Van Weel, Maria Vassilaki, R. Varraso, G. Viegi, D. Y. Wang, M. Wickman, D. Williams, S. Wöhrl, J. Wright, A. Yorgancioglu, O. M. Yusuf, H. J. Zar, M. E. Zernotti, M. Zidarn, N. Zhong, T. Zuberbier

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

Original languageEnglish (US)
Pages (from-to)216-231
Number of pages16
JournalInternational Archives of Allergy and Immunology
Volume158
Issue number3
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Asthma
Urticaria
Advisory Committees
Atopic Dermatitis
Rhinitis
Health Education
Comorbidity
Epidemiology
Chronic Disease
Public Health
Guidelines
Phenotype
Therapeutics
Research

Keywords

  • Asthma
  • Atopic dermatitis
  • Immunoglobulin E
  • Rhinitis
  • Rhinosinusitis
  • Urticaria

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bousquet, J., Anto, J. M., Demoly, P., Schünemann, H. J., Togias, A., Akdis, M., ... Zuberbier, T. (2012). Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper. International Archives of Allergy and Immunology, 158(3), 216-231. https://doi.org/10.1159/000332924

Severe chronic allergic (and related) diseases : A uniform approach - A MeDALL - GA2 LEN - ARIA position paper. / Bousquet, J.; Anto, J. M.; Demoly, P.; Schünemann, H. J.; Togias, A.; Akdis, M.; Auffray, C.; Bachert, C.; Bieber, T.; Bousquet, P. J.; Carlsen, K. H.; Casale, T. B.; Cruz, A. A.; Keil, T.; Lodrup Carlsen, K. C.; Maurer, M.; Ohta, K.; Papadopoulos, N. G.; Roman Rodriguez, M.; Samolinski, B.; Agache, I.; Andrianarisoa, A.; Ang, C. S.; Annesi-Maesano, I.; Ballester, F.; Baena-Cagnani, C. E.; Basagaña, X.; Bateman, E. D.; Bel, E. H.; Bedbrook, A.; Beghé, B.; Beji, M.; Ben Kheder, A.; Benet, M.; Bennoor, K. S.; Bergmann, K. C.; Berrissoul, F.; Bindslev Jensen, C.; Bleecker, E. R.; Bonini, S.; Boner, A. L.; Boulet, L. P.; Brightling, C. E.; Brozek, J. L.; Bush, A.; Busse, W. W.; Camargos, P. A.M.; Canonica, G. W.; Carr, W.; Cesario, A.; Chen, Y. Z.; Chiriac, A. M.; Costa, D. J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; Didi, T.; Dolen, W. K.; Douagui, H.; Dubakiene, R.; El-Meziane, A.; Fonseca, J. A.; Fokkens, W. J.; Fthenou, E.; Gamkrelidze, A.; Garcia-Aymerich, J.; Van Wijk, R. Gerth; Gimeno-Santos, E.; Guerra, S.; Haahtela, T.; Haddad, H.; Hellings, P. W.; Hellquist-Dahl, B.; Hohmann, C.; Howarth, P.; Hourihane, J. O.; Humbert, M.; Jacquemin, B.; Just, J.; Kalayci, O.; Kaliner, M. A.; Kauffmann, F.; Kerkhof, M.; Khayat, G.; Koffi N'Goran, B.; Kogevinas, M.; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kuna, P.; Larenas, D.; Lavi, I.; Le, L. T.; Lieberman, P.; Lipworth, B.; Mahboub, B.; Makela, M. J.; Martin, F.; Martinez, F. D.; Marshall, G. D.; Mazon, A.; Melen, E.; Meltzer, E. O.; Mihaltan, F.; Mohammad, Y.; Mohammadi, A.; Momas, I.; Morais-Almeida, M.; Mullol, J.; Muraro, A.; Naclerio, R.; Nafti, S.; Namazova-Baranova, L.; Nawijn, M. C.; Nyembue, T. D.; Oddie, S.; O'Hehir, R. E.; Okamoto, Y.; Orru, M. P.; Ozdemir, C.; Ouedraogo, G. S.; Palkonen, S.; Panzner, P.; Passalacqua, G.; Pawankar, R.; Pigearias, B.; Pin, I.; Pinart, M.; Pison, C.; Popov, T. A.; Porta, D.; Postma, D. S.; Price, D.; Rabe, K. F.; Ratomaharo, J.; Reitamo, S.; Rezagui, D.; Ring, J.; Roberts, R.; Roca, J.; Rogala, B.; Romano, A.; Rosado-Pinto, J.; Ryan, D.; Sanchez-Borges, M.; Scadding, G. K.; Sheikh, A.; Simons, F. E.R.; Siroux, V.; Schmid-Grendelmeier, P. D.; Smit, H. A.; Sooronbaev, T.; Stein, R. T.; Sterk, P. J.; Sunyer, J.; Terreehorst, I.; Toskala, E.; Tremblay, Y.; Valenta, R.; Valeyre, D.; Vandenplas, O.; Van Weel, C.; Vassilaki, Maria; Varraso, R.; Viegi, G.; Wang, D. Y.; Wickman, M.; Williams, D.; Wöhrl, S.; Wright, J.; Yorgancioglu, A.; Yusuf, O. M.; Zar, H. J.; Zernotti, M. E.; Zidarn, M.; Zhong, N.; Zuberbier, T.

In: International Archives of Allergy and Immunology, Vol. 158, No. 3, 01.06.2012, p. 216-231.

Research output: Contribution to journalArticle

Bousquet, J, Anto, JM, Demoly, P, Schünemann, HJ, Togias, A, Akdis, M, Auffray, C, Bachert, C, Bieber, T, Bousquet, PJ, Carlsen, KH, Casale, TB, Cruz, AA, Keil, T, Lodrup Carlsen, KC, Maurer, M, Ohta, K, Papadopoulos, NG, Roman Rodriguez, M, Samolinski, B, Agache, I, Andrianarisoa, A, Ang, CS, Annesi-Maesano, I, Ballester, F, Baena-Cagnani, CE, Basagaña, X, Bateman, ED, Bel, EH, Bedbrook, A, Beghé, B, Beji, M, Ben Kheder, A, Benet, M, Bennoor, KS, Bergmann, KC, Berrissoul, F, Bindslev Jensen, C, Bleecker, ER, Bonini, S, Boner, AL, Boulet, LP, Brightling, CE, Brozek, JL, Bush, A, Busse, WW, Camargos, PAM, Canonica, GW, Carr, W, Cesario, A, Chen, YZ, Chiriac, AM, Costa, DJ, Cox, L, Custovic, A, Dahl, R, Darsow, U, Didi, T, Dolen, WK, Douagui, H, Dubakiene, R, El-Meziane, A, Fonseca, JA, Fokkens, WJ, Fthenou, E, Gamkrelidze, A, Garcia-Aymerich, J, Van Wijk, RG, Gimeno-Santos, E, Guerra, S, Haahtela, T, Haddad, H, Hellings, PW, Hellquist-Dahl, B, Hohmann, C, Howarth, P, Hourihane, JO, Humbert, M, Jacquemin, B, Just, J, Kalayci, O, Kaliner, MA, Kauffmann, F, Kerkhof, M, Khayat, G, Koffi N'Goran, B, Kogevinas, M, Koppelman, GH, Kowalski, ML, Kull, I, Kuna, P, Larenas, D, Lavi, I, Le, LT, Lieberman, P, Lipworth, B, Mahboub, B, Makela, MJ, Martin, F, Martinez, FD, Marshall, GD, Mazon, A, Melen, E, Meltzer, EO, Mihaltan, F, Mohammad, Y, Mohammadi, A, Momas, I, Morais-Almeida, M, Mullol, J, Muraro, A, Naclerio, R, Nafti, S, Namazova-Baranova, L, Nawijn, MC, Nyembue, TD, Oddie, S, O'Hehir, RE, Okamoto, Y, Orru, MP, Ozdemir, C, Ouedraogo, GS, Palkonen, S, Panzner, P, Passalacqua, G, Pawankar, R, Pigearias, B, Pin, I, Pinart, M, Pison, C, Popov, TA, Porta, D, Postma, DS, Price, D, Rabe, KF, Ratomaharo, J, Reitamo, S, Rezagui, D, Ring, J, Roberts, R, Roca, J, Rogala, B, Romano, A, Rosado-Pinto, J, Ryan, D, Sanchez-Borges, M, Scadding, GK, Sheikh, A, Simons, FER, Siroux, V, Schmid-Grendelmeier, PD, Smit, HA, Sooronbaev, T, Stein, RT, Sterk, PJ, Sunyer, J, Terreehorst, I, Toskala, E, Tremblay, Y, Valenta, R, Valeyre, D, Vandenplas, O, Van Weel, C, Vassilaki, M, Varraso, R, Viegi, G, Wang, DY, Wickman, M, Williams, D, Wöhrl, S, Wright, J, Yorgancioglu, A, Yusuf, OM, Zar, HJ, Zernotti, ME, Zidarn, M, Zhong, N & Zuberbier, T 2012, 'Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper', International Archives of Allergy and Immunology, vol. 158, no. 3, pp. 216-231. https://doi.org/10.1159/000332924
Bousquet, J. ; Anto, J. M. ; Demoly, P. ; Schünemann, H. J. ; Togias, A. ; Akdis, M. ; Auffray, C. ; Bachert, C. ; Bieber, T. ; Bousquet, P. J. ; Carlsen, K. H. ; Casale, T. B. ; Cruz, A. A. ; Keil, T. ; Lodrup Carlsen, K. C. ; Maurer, M. ; Ohta, K. ; Papadopoulos, N. G. ; Roman Rodriguez, M. ; Samolinski, B. ; Agache, I. ; Andrianarisoa, A. ; Ang, C. S. ; Annesi-Maesano, I. ; Ballester, F. ; Baena-Cagnani, C. E. ; Basagaña, X. ; Bateman, E. D. ; Bel, E. H. ; Bedbrook, A. ; Beghé, B. ; Beji, M. ; Ben Kheder, A. ; Benet, M. ; Bennoor, K. S. ; Bergmann, K. C. ; Berrissoul, F. ; Bindslev Jensen, C. ; Bleecker, E. R. ; Bonini, S. ; Boner, A. L. ; Boulet, L. P. ; Brightling, C. E. ; Brozek, J. L. ; Bush, A. ; Busse, W. W. ; Camargos, P. A.M. ; Canonica, G. W. ; Carr, W. ; Cesario, A. ; Chen, Y. Z. ; Chiriac, A. M. ; Costa, D. J. ; Cox, L. ; Custovic, A. ; Dahl, R. ; Darsow, U. ; Didi, T. ; Dolen, W. K. ; Douagui, H. ; Dubakiene, R. ; El-Meziane, A. ; Fonseca, J. A. ; Fokkens, W. J. ; Fthenou, E. ; Gamkrelidze, A. ; Garcia-Aymerich, J. ; Van Wijk, R. Gerth ; Gimeno-Santos, E. ; Guerra, S. ; Haahtela, T. ; Haddad, H. ; Hellings, P. W. ; Hellquist-Dahl, B. ; Hohmann, C. ; Howarth, P. ; Hourihane, J. O. ; Humbert, M. ; Jacquemin, B. ; Just, J. ; Kalayci, O. ; Kaliner, M. A. ; Kauffmann, F. ; Kerkhof, M. ; Khayat, G. ; Koffi N'Goran, B. ; Kogevinas, M. ; Koppelman, G. H. ; Kowalski, M. L. ; Kull, I. ; Kuna, P. ; Larenas, D. ; Lavi, I. ; Le, L. T. ; Lieberman, P. ; Lipworth, B. ; Mahboub, B. ; Makela, M. J. ; Martin, F. ; Martinez, F. D. ; Marshall, G. D. ; Mazon, A. ; Melen, E. ; Meltzer, E. O. ; Mihaltan, F. ; Mohammad, Y. ; Mohammadi, A. ; Momas, I. ; Morais-Almeida, M. ; Mullol, J. ; Muraro, A. ; Naclerio, R. ; Nafti, S. ; Namazova-Baranova, L. ; Nawijn, M. C. ; Nyembue, T. D. ; Oddie, S. ; O'Hehir, R. E. ; Okamoto, Y. ; Orru, M. P. ; Ozdemir, C. ; Ouedraogo, G. S. ; Palkonen, S. ; Panzner, P. ; Passalacqua, G. ; Pawankar, R. ; Pigearias, B. ; Pin, I. ; Pinart, M. ; Pison, C. ; Popov, T. A. ; Porta, D. ; Postma, D. S. ; Price, D. ; Rabe, K. F. ; Ratomaharo, J. ; Reitamo, S. ; Rezagui, D. ; Ring, J. ; Roberts, R. ; Roca, J. ; Rogala, B. ; Romano, A. ; Rosado-Pinto, J. ; Ryan, D. ; Sanchez-Borges, M. ; Scadding, G. K. ; Sheikh, A. ; Simons, F. E.R. ; Siroux, V. ; Schmid-Grendelmeier, P. D. ; Smit, H. A. ; Sooronbaev, T. ; Stein, R. T. ; Sterk, P. J. ; Sunyer, J. ; Terreehorst, I. ; Toskala, E. ; Tremblay, Y. ; Valenta, R. ; Valeyre, D. ; Vandenplas, O. ; Van Weel, C. ; Vassilaki, Maria ; Varraso, R. ; Viegi, G. ; Wang, D. Y. ; Wickman, M. ; Williams, D. ; Wöhrl, S. ; Wright, J. ; Yorgancioglu, A. ; Yusuf, O. M. ; Zar, H. J. ; Zernotti, M. E. ; Zidarn, M. ; Zhong, N. ; Zuberbier, T. / Severe chronic allergic (and related) diseases : A uniform approach - A MeDALL - GA2 LEN - ARIA position paper. In: International Archives of Allergy and Immunology. 2012 ; Vol. 158, No. 3. pp. 216-231.
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title = "Severe chronic allergic (and related) diseases: A uniform approach - A MeDALL - GA2 LEN - ARIA position paper",
abstract = "Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.",
keywords = "Asthma, Atopic dermatitis, Immunoglobulin E, Rhinitis, Rhinosinusitis, Urticaria",
author = "J. Bousquet and Anto, {J. M.} and P. Demoly and Sch{\"u}nemann, {H. J.} and A. Togias and M. Akdis and C. Auffray and C. Bachert and T. Bieber and Bousquet, {P. J.} and Carlsen, {K. H.} and Casale, {T. B.} and Cruz, {A. A.} and T. Keil and {Lodrup Carlsen}, {K. C.} and M. Maurer and K. Ohta and Papadopoulos, {N. G.} and {Roman Rodriguez}, M. and B. Samolinski and I. Agache and A. Andrianarisoa and Ang, {C. S.} and I. Annesi-Maesano and F. Ballester and Baena-Cagnani, {C. E.} and X. Basaga{\~n}a and Bateman, {E. D.} and Bel, {E. H.} and A. Bedbrook and B. Begh{\'e} and M. Beji and {Ben Kheder}, A. and M. Benet and Bennoor, {K. S.} and Bergmann, {K. C.} and F. Berrissoul and {Bindslev Jensen}, C. and Bleecker, {E. R.} and S. Bonini and Boner, {A. L.} and Boulet, {L. P.} and Brightling, {C. E.} and Brozek, {J. L.} and A. Bush and Busse, {W. W.} and Camargos, {P. A.M.} and Canonica, {G. W.} and W. Carr and A. Cesario and Chen, {Y. Z.} and Chiriac, {A. M.} and Costa, {D. J.} and L. Cox and A. Custovic and R. Dahl and U. Darsow and T. Didi and Dolen, {W. K.} and H. Douagui and R. Dubakiene and A. El-Meziane and Fonseca, {J. A.} and Fokkens, {W. J.} and E. Fthenou and A. Gamkrelidze and J. Garcia-Aymerich and {Van Wijk}, {R. Gerth} and E. Gimeno-Santos and S. Guerra and T. Haahtela and H. Haddad and Hellings, {P. W.} and B. Hellquist-Dahl and C. Hohmann and P. Howarth and Hourihane, {J. O.} and M. Humbert and B. Jacquemin and J. Just and O. Kalayci and Kaliner, {M. A.} and F. Kauffmann and M. Kerkhof and G. Khayat and {Koffi N'Goran}, B. and M. Kogevinas and Koppelman, {G. H.} and Kowalski, {M. L.} and I. Kull and P. Kuna and D. Larenas and I. Lavi and Le, {L. T.} and P. Lieberman and B. Lipworth and B. Mahboub and Makela, {M. J.} and F. Martin and Martinez, {F. D.} and Marshall, {G. D.} and A. Mazon and E. Melen and Meltzer, {E. O.} and F. Mihaltan and Y. Mohammad and A. Mohammadi and I. Momas and M. Morais-Almeida and J. Mullol and A. Muraro and R. Naclerio and S. Nafti and L. Namazova-Baranova and Nawijn, {M. C.} and Nyembue, {T. D.} and S. Oddie and O'Hehir, {R. E.} and Y. Okamoto and Orru, {M. P.} and C. Ozdemir and Ouedraogo, {G. S.} and S. Palkonen and P. Panzner and G. Passalacqua and R. Pawankar and B. Pigearias and I. Pin and M. Pinart and C. Pison and Popov, {T. A.} and D. Porta and Postma, {D. S.} and D. Price and Rabe, {K. F.} and J. Ratomaharo and S. Reitamo and D. Rezagui and J. Ring and R. Roberts and J. Roca and B. Rogala and A. Romano and J. Rosado-Pinto and D. Ryan and M. Sanchez-Borges and Scadding, {G. K.} and A. Sheikh and Simons, {F. E.R.} and V. Siroux and Schmid-Grendelmeier, {P. D.} and Smit, {H. A.} and T. Sooronbaev and Stein, {R. T.} and Sterk, {P. J.} and J. Sunyer and I. Terreehorst and E. Toskala and Y. Tremblay and R. Valenta and D. Valeyre and O. Vandenplas and {Van Weel}, C. and Maria Vassilaki and R. Varraso and G. Viegi and Wang, {D. Y.} and M. Wickman and D. Williams and S. W{\"o}hrl and J. Wright and A. Yorgancioglu and Yusuf, {O. M.} and Zar, {H. J.} and Zernotti, {M. E.} and M. Zidarn and N. Zhong and T. Zuberbier",
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TY - JOUR

T1 - Severe chronic allergic (and related) diseases

T2 - A uniform approach - A MeDALL - GA2 LEN - ARIA position paper

AU - Bousquet, J.

AU - Anto, J. M.

AU - Demoly, P.

AU - Schünemann, H. J.

AU - Togias, A.

AU - Akdis, M.

AU - Auffray, C.

AU - Bachert, C.

AU - Bieber, T.

AU - Bousquet, P. J.

AU - Carlsen, K. H.

AU - Casale, T. B.

AU - Cruz, A. A.

AU - Keil, T.

AU - Lodrup Carlsen, K. C.

AU - Maurer, M.

AU - Ohta, K.

AU - Papadopoulos, N. G.

AU - Roman Rodriguez, M.

AU - Samolinski, B.

AU - Agache, I.

AU - Andrianarisoa, A.

AU - Ang, C. S.

AU - Annesi-Maesano, I.

AU - Ballester, F.

AU - Baena-Cagnani, C. E.

AU - Basagaña, X.

AU - Bateman, E. D.

AU - Bel, E. H.

AU - Bedbrook, A.

AU - Beghé, B.

AU - Beji, M.

AU - Ben Kheder, A.

AU - Benet, M.

AU - Bennoor, K. S.

AU - Bergmann, K. C.

AU - Berrissoul, F.

AU - Bindslev Jensen, C.

AU - Bleecker, E. R.

AU - Bonini, S.

AU - Boner, A. L.

AU - Boulet, L. P.

AU - Brightling, C. E.

AU - Brozek, J. L.

AU - Bush, A.

AU - Busse, W. W.

AU - Camargos, P. A.M.

AU - Canonica, G. W.

AU - Carr, W.

AU - Cesario, A.

AU - Chen, Y. Z.

AU - Chiriac, A. M.

AU - Costa, D. J.

AU - Cox, L.

AU - Custovic, A.

AU - Dahl, R.

AU - Darsow, U.

AU - Didi, T.

AU - Dolen, W. K.

AU - Douagui, H.

AU - Dubakiene, R.

AU - El-Meziane, A.

AU - Fonseca, J. A.

AU - Fokkens, W. J.

AU - Fthenou, E.

AU - Gamkrelidze, A.

AU - Garcia-Aymerich, J.

AU - Van Wijk, R. Gerth

AU - Gimeno-Santos, E.

AU - Guerra, S.

AU - Haahtela, T.

AU - Haddad, H.

AU - Hellings, P. W.

AU - Hellquist-Dahl, B.

AU - Hohmann, C.

AU - Howarth, P.

AU - Hourihane, J. O.

AU - Humbert, M.

AU - Jacquemin, B.

AU - Just, J.

AU - Kalayci, O.

AU - Kaliner, M. A.

AU - Kauffmann, F.

AU - Kerkhof, M.

AU - Khayat, G.

AU - Koffi N'Goran, B.

AU - Kogevinas, M.

AU - Koppelman, G. H.

AU - Kowalski, M. L.

AU - Kull, I.

AU - Kuna, P.

AU - Larenas, D.

AU - Lavi, I.

AU - Le, L. T.

AU - Lieberman, P.

AU - Lipworth, B.

AU - Mahboub, B.

AU - Makela, M. J.

AU - Martin, F.

AU - Martinez, F. D.

AU - Marshall, G. D.

AU - Mazon, A.

AU - Melen, E.

AU - Meltzer, E. O.

AU - Mihaltan, F.

AU - Mohammad, Y.

AU - Mohammadi, A.

AU - Momas, I.

AU - Morais-Almeida, M.

AU - Mullol, J.

AU - Muraro, A.

AU - Naclerio, R.

AU - Nafti, S.

AU - Namazova-Baranova, L.

AU - Nawijn, M. C.

AU - Nyembue, T. D.

AU - Oddie, S.

AU - O'Hehir, R. E.

AU - Okamoto, Y.

AU - Orru, M. P.

AU - Ozdemir, C.

AU - Ouedraogo, G. S.

AU - Palkonen, S.

AU - Panzner, P.

AU - Passalacqua, G.

AU - Pawankar, R.

AU - Pigearias, B.

AU - Pin, I.

AU - Pinart, M.

AU - Pison, C.

AU - Popov, T. A.

AU - Porta, D.

AU - Postma, D. S.

AU - Price, D.

AU - Rabe, K. F.

AU - Ratomaharo, J.

AU - Reitamo, S.

AU - Rezagui, D.

AU - Ring, J.

AU - Roberts, R.

AU - Roca, J.

AU - Rogala, B.

AU - Romano, A.

AU - Rosado-Pinto, J.

AU - Ryan, D.

AU - Sanchez-Borges, M.

AU - Scadding, G. K.

AU - Sheikh, A.

AU - Simons, F. E.R.

AU - Siroux, V.

AU - Schmid-Grendelmeier, P. D.

AU - Smit, H. A.

AU - Sooronbaev, T.

AU - Stein, R. T.

AU - Sterk, P. J.

AU - Sunyer, J.

AU - Terreehorst, I.

AU - Toskala, E.

AU - Tremblay, Y.

AU - Valenta, R.

AU - Valeyre, D.

AU - Vandenplas, O.

AU - Van Weel, C.

AU - Vassilaki, Maria

AU - Varraso, R.

AU - Viegi, G.

AU - Wang, D. Y.

AU - Wickman, M.

AU - Williams, D.

AU - Wöhrl, S.

AU - Wright, J.

AU - Yorgancioglu, A.

AU - Yusuf, O. M.

AU - Zar, H. J.

AU - Zernotti, M. E.

AU - Zidarn, M.

AU - Zhong, N.

AU - Zuberbier, T.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

AB - Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

KW - Asthma

KW - Atopic dermatitis

KW - Immunoglobulin E

KW - Rhinitis

KW - Rhinosinusitis

KW - Urticaria

UR - http://www.scopus.com/inward/record.url?scp=84862136708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862136708&partnerID=8YFLogxK

U2 - 10.1159/000332924

DO - 10.1159/000332924

M3 - Article

C2 - 22382913

AN - SCOPUS:84862136708

VL - 158

SP - 216

EP - 231

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 3

ER -