Severe autoimmune neutropenia associated with acute autoimmune hepatitis

Ahmad M. Wehbe, Birgir Johannsson, Thomas J. Raife, Michelle Bleile, Adam Bell, Brian R. Curtis, Thorvardur R. Halfdanarson

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.

Original languageEnglish (US)
Pages (from-to)673-678
Number of pages6
JournalInternational journal of hematology
Volume91
Issue number4
DOIs
StatePublished - May 1 2010

    Fingerprint

Keywords

  • Autoimmune hepatitis
  • Autoimmune neutropenia
  • Immune neutropenia
  • Neutropenia
  • Neutrophil antibodies

ASJC Scopus subject areas

  • Hematology

Cite this

Wehbe, A. M., Johannsson, B., Raife, T. J., Bleile, M., Bell, A., Curtis, B. R., & Halfdanarson, T. R. (2010). Severe autoimmune neutropenia associated with acute autoimmune hepatitis. International journal of hematology, 91(4), 673-678. https://doi.org/10.1007/s12185-010-0557-1