Severe autoimmune neutropenia associated with acute autoimmune hepatitis

Ahmad M. Wehbe; Birgir Johannsson; Thomas J. Raife; Michelle Bleile; Adam Bell; Brian R. Curtis; Thorvardur R. Halfdanarson

doi:10.1007/s12185-010-0557-1

Severe autoimmune neutropenia associated with acute autoimmune hepatitis

Ahmad M. Wehbe, Birgir Johannsson, Thomas J. Raife, Michelle Bleile, Adam Bell, Brian R. Curtis, Thorvardur R. Halfdanarson

Medical Oncology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm³), normal hemoglobin and mild thrombocytopenia (115000/mm³). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.

Original language	English (US)
Pages (from-to)	673-678
Number of pages	6
Journal	International journal of hematology
Volume	91
Issue number	4
DOIs	https://doi.org/10.1007/s12185-010-0557-1
State	Published - May 2010

Keywords

Autoimmune hepatitis
Autoimmune neutropenia
Immune neutropenia
Neutropenia
Neutrophil antibodies

ASJC Scopus subject areas

Hematology

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10.1007/s12185-010-0557-1

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title = "Severe autoimmune neutropenia associated with acute autoimmune hepatitis",

abstract = "A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.",

keywords = "Autoimmune hepatitis, Autoimmune neutropenia, Immune neutropenia, Neutropenia, Neutrophil antibodies",

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AU - Wehbe, Ahmad M.

AU - Johannsson, Birgir

AU - Raife, Thomas J.

AU - Bleile, Michelle

AU - Bell, Adam

AU - Curtis, Brian R.

AU - Halfdanarson, Thorvardur R.

PY - 2010/5

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N2 - A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.

AB - A 49-year-old previously healthy female presented with acute hepatitis and severe neutropenia. A diagnosis of type 1 autoimmune hepatitis was made based on the histological appearance of a liver core biopsy, positive anti-smooth muscle antibodies, and positive anti-neutrophil cytoplasmic antibody (atypical ANCA). Hemogram revealed mild leukopenia with severe neutropenia (absolute neutrophil count 256/mm3), normal hemoglobin and mild thrombocytopenia (115000/mm3). A bone marrow biopsy and aspirate had a normal karyotype, increase in granulopoiesis, prominence of promyelocytes (31%) and absence of mature granulocytes. Anti-neutrophil antibodies were detected in the patient's blood. Therapy was directed at the underlying hepatitis with resolution of neutropenia without the use of colony-stimulating factors.

KW - Autoimmune hepatitis

KW - Autoimmune neutropenia

KW - Immune neutropenia

KW - Neutropenia

KW - Neutrophil antibodies

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Severe autoimmune neutropenia associated with acute autoimmune hepatitis

Abstract

Keywords

ASJC Scopus subject areas

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