Abstract
Introduction: Severe anion gap (AG) acidosis associated with intravenous sodium thiosulfate (STS) administration has not been previously described in nondialysis chronic kidney disease (CKD) patients. Case Report: We present a CKD patient with a baseline creatinine 1.8 mg/dL (eGFR 28 ml/min/1.73 m2) who developed sustained and life-threatening AG acidosis associated with intravenous STS treatment for calciphylaxis. Discussion: Although marketed as a safe drug, STS can cause life-threatening acidosis as illustrated in this case. STS-induced AG acidosis should be considered in the differential diagnosis of severe acidosis in patients receiving STS. Dosage adjustment and close follow-up of patients' acid-base status after STS initiation is necessary.
Original language | English (US) |
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Pages (from-to) | 274-277 |
Number of pages | 4 |
Journal | Journal of Medical Toxicology |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2013 |
Keywords
- Anion gap acidosis
- Calciphylaxis
- Chronic kidney disease
- GOLD MARKS
- Sodium thiosulfate (STS)
ASJC Scopus subject areas
- Toxicology
- Health, Toxicology and Mutagenesis