Severe alveolar proteinosis following chemotherapy for acute myeloid leukemia in a lung allograft recipient

Emma Z. Du, Gordon L. Yung, Dzung T. Le, Eliezer Masliah, Eunhee S. Yi, Paul J. Friedman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A 64-year-old man was diagnosed with acute myeloid leukemia (AML) 5 years following single lung transplantation performed for severe pulmonary hypertension from scleroderma. Chemotherapy for treatment of AML with fludarabine, cytosine arabinoside, G-CSF (FLAG) regimen was initiated. Despite intensive antibiotic treatment for a presumptive diagnosis of bacterial pneumonia, the patient developed acute respiratory failure and died before a complete cycle of chemotherapy could be administered. At autopsy, both native and allograft lungs showed widespread alveolar proteinosis that was determined as the main cause of acute respiratory failure. Alveolar proteinosis, a potentially treatable disease, should be considered in the radiologic differential diagnosis of diffuse lung disease in this clinical setting.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
JournalJournal of Thoracic Imaging
Volume16
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Acute Myeloid Leukemia
Respiratory Insufficiency
Allografts
Bacterial Pneumonia
Drug Therapy
Lung
Lung Transplantation
Cytarabine
Granulocyte Colony-Stimulating Factor
Pulmonary Hypertension
Lung Diseases
Autopsy
Differential Diagnosis
Anti-Bacterial Agents
Therapeutics
fludarabine

Keywords

  • Acute myeloid leukemia
  • Chemotherapy
  • FLAG
  • Lung transplantation
  • Pulmonary alveolar proteinosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Severe alveolar proteinosis following chemotherapy for acute myeloid leukemia in a lung allograft recipient. / Du, Emma Z.; Yung, Gordon L.; Le, Dzung T.; Masliah, Eliezer; Yi, Eunhee S.; Friedman, Paul J.

In: Journal of Thoracic Imaging, Vol. 16, No. 4, 2001, p. 307-309.

Research output: Contribution to journalArticle

Du, Emma Z. ; Yung, Gordon L. ; Le, Dzung T. ; Masliah, Eliezer ; Yi, Eunhee S. ; Friedman, Paul J. / Severe alveolar proteinosis following chemotherapy for acute myeloid leukemia in a lung allograft recipient. In: Journal of Thoracic Imaging. 2001 ; Vol. 16, No. 4. pp. 307-309.
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