Severe alveolar proteinosis following chemotherapy for acute myeloid leukemia in a lung allograft recipient

Emma Z. Du, Gordon L. Yung, Dzung T. Le, Eliezer Masliah, Eunhee S. Yi, Paul J. Friedman

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A 64-year-old man was diagnosed with acute myeloid leukemia (AML) 5 years following single lung transplantation performed for severe pulmonary hypertension from scleroderma. Chemotherapy for treatment of AML with fludarabine, cytosine arabinoside, G-CSF (FLAG) regimen was initiated. Despite intensive antibiotic treatment for a presumptive diagnosis of bacterial pneumonia, the patient developed acute respiratory failure and died before a complete cycle of chemotherapy could be administered. At autopsy, both native and allograft lungs showed widespread alveolar proteinosis that was determined as the main cause of acute respiratory failure. Alveolar proteinosis, a potentially treatable disease, should be considered in the radiologic differential diagnosis of diffuse lung disease in this clinical setting.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
JournalJournal of Thoracic Imaging
Volume16
Issue number4
DOIs
StatePublished - Nov 20 2001

Keywords

  • Acute myeloid leukemia
  • Chemotherapy
  • FLAG
  • Lung transplantation
  • Pulmonary alveolar proteinosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine

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