Abstract
Aims: To determine the prevalence of various colonic polyps removed during a recent 8-month period; to determine the interobserver agreement in the diagnosis of serrated polyps; and to determine if harbouring a sessile serrated adenoma (SSA) predisposes to the presence of synchronous polyps with similar histology. Methods and results: All polyps resected during an 8-month period at a single tertiary medical centre were analysed. We also analysed all polyps in patients with an SSA or SSA with dysplasia since 2003. SSAs accounted for 4.3% of colonic polyps removed during an 8-month period. A review of 276 serrated polyps by two pathologists revealed good interobserver agreement (κ = 0.66). Patients with one SSA were more likely to harbour additional serrated polyps. After removal of the index SSA, 18% of their remaining polyps were SSAs, SSAs with dysplasia, and traditional serrated adenomas, contrasting with the ∼5% prevalence of these polyps in the control population. The hyperplastic polyps in the study population were also twice as likely to occur proximal to the splenic flexure. Conclusions: These data indicate that there is a strong colonic mucosal field defect in patients with sporadic SSAs that predispose them to develop additional serrated polyps.
Original language | English (US) |
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Pages (from-to) | 581-588 |
Number of pages | 8 |
Journal | Histopathology |
Volume | 56 |
Issue number | 5 |
DOIs | |
State | Published - Apr 2010 |
Keywords
- CIMP
- Colonic cancer
- CpG island methylation
- Hyperplastic polyp
- Hyperplastic polyposis syndrome
- Microsatellite instability
- Sessile serrated adenoma
- Sessile serrated polyp
- Traditional serrated adenoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology