Sesquiterpene lactones from Achillea crithmifolia

S. Milosavljevic, S. Macura, M. Stefanovic, I. Aljancic, D. Milinkovk

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The isolation of three highly oxygenated guaianolides, desacetyl-1α-4α- dihydroxybishopsolicepolide [1], its 4β-hydroxy epimer 2 (a new compound), and 1β,2β:3β,4β-diepoxy-8α,10α-dihydroxyguai-12(13)-en-12,6α-olide [3], from the aerial parts of Achillea crithmifolia is reported. Because lactone 3 was shown to be identical with rupin A, the initially proposed 1α,2α:3α,4α-diepoxy stereochemistry of rupin A should be revised.

Original languageEnglish (US)
Pages (from-to)64-67
Number of pages4
JournalJournal of Natural Products
Volume57
Issue number1
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Milosavljevic, S., Macura, S., Stefanovic, M., Aljancic, I., & Milinkovk, D. (1994). Sesquiterpene lactones from Achillea crithmifolia. Journal of Natural Products, 57(1), 64-67. https://doi.org/10.1021/np50103a008