Serum uric acid is associated with cardiovascular events in patients with coronary artery disease

Jang Ho Bae, Dae Woo Hyun, Taek Geun Kwon, Hyun Ju Yoon, Amir Lerman, Charanjit S. Rihal

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background and Objectives : Whether uric acid is a predictor of cardiovascular events remains controversial. We sought to evaluate the effects of the serum uric acid levels on major adverse cardiovascular events (MACEs) in the patients with coronary artery disease (CAD). Subjects and Methods : The study population consisted of 660 consecutive patients with CAD, and they were followed up for a mean of 27 months (maximum: 62 months). The recorded MACEs included acute myocardial infarction (AMI), stroke, coronary artery bypass graft, percutaneous coronary intervention (PCI) due to de novo lesion during follow up, congestive heart failure (CHF) and sudden cardiac death. Results : In the CAD patients with a uric acid level ≤3.88 mg/dL (the lowest quartile), as compared with those CAD patients with uric acid levels >5.74 mg/dL (the highest quartile), the MACE rate increased from 7.2% to 20.1%. On univariate Cox regression analysis, the highest uric acid quartile was a predictor of AMI, CHF and MACE. The absolute serum uric acid level was predictive of PCI, CHF and MACE. Multivariate Cox regression analysis showed that the independent predictors of MACE were presentation with acute coronary syndrome (HR 1.70, 95% CI: 1.04 to 2.78, p=0.033), multi-vessel disease (HR 2.43, 95% CI: 1.44 to 4.12, p=0.001), and the uric acid levels (HR 1.22, 95% CI: 1.05 to 1.43, p=0.010), and the highest uric acid quartile (HR 2.54, 95% CI: 1.58 to 4.10, p<0.001). Conclusion : The serum uric acid level and multi-vessel disease are associated with subsequent cardiovascular events in the patients with CAD.

Original languageEnglish (US)
Pages (from-to)161-166
Number of pages6
JournalKorean Circulation Journal
Volume37
Issue number4
StatePublished - Apr 2007

Fingerprint

Uric Acid
Coronary Artery Disease
Serum
Heart Failure
Percutaneous Coronary Intervention
Myocardial Infarction
Regression Analysis
Sudden Cardiac Death
Acute Coronary Syndrome
Coronary Artery Bypass
Stroke
Transplants
Population

Keywords

  • Coronary artery disease
  • Prognosis
  • Uric acid

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Bae, J. H., Hyun, D. W., Kwon, T. G., Yoon, H. J., Lerman, A., & Rihal, C. S. (2007). Serum uric acid is associated with cardiovascular events in patients with coronary artery disease. Korean Circulation Journal, 37(4), 161-166.

Serum uric acid is associated with cardiovascular events in patients with coronary artery disease. / Bae, Jang Ho; Hyun, Dae Woo; Kwon, Taek Geun; Yoon, Hyun Ju; Lerman, Amir; Rihal, Charanjit S.

In: Korean Circulation Journal, Vol. 37, No. 4, 04.2007, p. 161-166.

Research output: Contribution to journalArticle

Bae, JH, Hyun, DW, Kwon, TG, Yoon, HJ, Lerman, A & Rihal, CS 2007, 'Serum uric acid is associated with cardiovascular events in patients with coronary artery disease', Korean Circulation Journal, vol. 37, no. 4, pp. 161-166.
Bae, Jang Ho ; Hyun, Dae Woo ; Kwon, Taek Geun ; Yoon, Hyun Ju ; Lerman, Amir ; Rihal, Charanjit S. / Serum uric acid is associated with cardiovascular events in patients with coronary artery disease. In: Korean Circulation Journal. 2007 ; Vol. 37, No. 4. pp. 161-166.
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abstract = "Background and Objectives : Whether uric acid is a predictor of cardiovascular events remains controversial. We sought to evaluate the effects of the serum uric acid levels on major adverse cardiovascular events (MACEs) in the patients with coronary artery disease (CAD). Subjects and Methods : The study population consisted of 660 consecutive patients with CAD, and they were followed up for a mean of 27 months (maximum: 62 months). The recorded MACEs included acute myocardial infarction (AMI), stroke, coronary artery bypass graft, percutaneous coronary intervention (PCI) due to de novo lesion during follow up, congestive heart failure (CHF) and sudden cardiac death. Results : In the CAD patients with a uric acid level ≤3.88 mg/dL (the lowest quartile), as compared with those CAD patients with uric acid levels >5.74 mg/dL (the highest quartile), the MACE rate increased from 7.2{\%} to 20.1{\%}. On univariate Cox regression analysis, the highest uric acid quartile was a predictor of AMI, CHF and MACE. The absolute serum uric acid level was predictive of PCI, CHF and MACE. Multivariate Cox regression analysis showed that the independent predictors of MACE were presentation with acute coronary syndrome (HR 1.70, 95{\%} CI: 1.04 to 2.78, p=0.033), multi-vessel disease (HR 2.43, 95{\%} CI: 1.44 to 4.12, p=0.001), and the uric acid levels (HR 1.22, 95{\%} CI: 1.05 to 1.43, p=0.010), and the highest uric acid quartile (HR 2.54, 95{\%} CI: 1.58 to 4.10, p<0.001). Conclusion : The serum uric acid level and multi-vessel disease are associated with subsequent cardiovascular events in the patients with CAD.",
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AB - Background and Objectives : Whether uric acid is a predictor of cardiovascular events remains controversial. We sought to evaluate the effects of the serum uric acid levels on major adverse cardiovascular events (MACEs) in the patients with coronary artery disease (CAD). Subjects and Methods : The study population consisted of 660 consecutive patients with CAD, and they were followed up for a mean of 27 months (maximum: 62 months). The recorded MACEs included acute myocardial infarction (AMI), stroke, coronary artery bypass graft, percutaneous coronary intervention (PCI) due to de novo lesion during follow up, congestive heart failure (CHF) and sudden cardiac death. Results : In the CAD patients with a uric acid level ≤3.88 mg/dL (the lowest quartile), as compared with those CAD patients with uric acid levels >5.74 mg/dL (the highest quartile), the MACE rate increased from 7.2% to 20.1%. On univariate Cox regression analysis, the highest uric acid quartile was a predictor of AMI, CHF and MACE. The absolute serum uric acid level was predictive of PCI, CHF and MACE. Multivariate Cox regression analysis showed that the independent predictors of MACE were presentation with acute coronary syndrome (HR 1.70, 95% CI: 1.04 to 2.78, p=0.033), multi-vessel disease (HR 2.43, 95% CI: 1.44 to 4.12, p=0.001), and the uric acid levels (HR 1.22, 95% CI: 1.05 to 1.43, p=0.010), and the highest uric acid quartile (HR 2.54, 95% CI: 1.58 to 4.10, p<0.001). Conclusion : The serum uric acid level and multi-vessel disease are associated with subsequent cardiovascular events in the patients with CAD.

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