Serum sex hormones and measures of benign prostatic hyperplasia

Rosebud O Roberts, Debra J. Jacobson, Thomas Rhodes, George G. Klee, Michael M. Leiber, Steven J. Jacobsen

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

BACKGROUND. Despite biologic plausibility, the associations between sex hormones and measures of benign prostatic hyperplasia (BPH) have not been consistently reported. METHODS. Subjects were randomly selected from the Olmsted County, MN population (n, 320; median age, 60.9 years) and followed biennially since 1990. In 2002, surrogate measures of BPH were assessed from an approximation of the American Urological Association Symptom Index (AUASI), Peak urinary flow rates (Qmax), and a transrectal ultrasound assessment of prostate volume. Serum levels of prostate specific antigen (PSA), testosterone, bioavailable testosterone, and estradiol were also measured. RESULTS. Bioavailable testosterone levels declined with increasing cross-sectional age from 53.8, 50.2, to 41.2 ng/dl (P = 0.001) in men aged <60, 60-69, and >69 years, respectively, and the estradiol/bioavailable testosterone ratio increased from 0.042, 0.044, to 0.050 (P = 0.04). Among men with bioavailable testosterone above the median, estradiol levels had a dose response relationship with prostate size. Among men with bioavailable testosterone level ≤ the median, however, there was no association between estradiol level and prostate volume CONCLUSIONS. While cross-sectional, these findings suggest a more complex relationship between sex steroids and prostate volume in older men than simple independent effects.

Original languageEnglish (US)
Pages (from-to)124-131
Number of pages8
JournalProstate
Volume61
Issue number2
DOIs
StatePublished - Oct 1 2004

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Prostatic Hyperplasia
Gonadal Steroid Hormones
Testosterone
Prostate
Estradiol
Serum
Prostate-Specific Antigen
Steroids
Population

Keywords

  • Benign prostatic hyperplasia
  • Cross-sectional
  • Peak flow rate
  • Prostate volume
  • Sex hormones
  • Symptoms

ASJC Scopus subject areas

  • Urology

Cite this

Roberts, R. O., Jacobson, D. J., Rhodes, T., Klee, G. G., Leiber, M. M., & Jacobsen, S. J. (2004). Serum sex hormones and measures of benign prostatic hyperplasia. Prostate, 61(2), 124-131. https://doi.org/10.1002/pros.20080

Serum sex hormones and measures of benign prostatic hyperplasia. / Roberts, Rosebud O; Jacobson, Debra J.; Rhodes, Thomas; Klee, George G.; Leiber, Michael M.; Jacobsen, Steven J.

In: Prostate, Vol. 61, No. 2, 01.10.2004, p. 124-131.

Research output: Contribution to journalArticle

Roberts, RO, Jacobson, DJ, Rhodes, T, Klee, GG, Leiber, MM & Jacobsen, SJ 2004, 'Serum sex hormones and measures of benign prostatic hyperplasia', Prostate, vol. 61, no. 2, pp. 124-131. https://doi.org/10.1002/pros.20080
Roberts RO, Jacobson DJ, Rhodes T, Klee GG, Leiber MM, Jacobsen SJ. Serum sex hormones and measures of benign prostatic hyperplasia. Prostate. 2004 Oct 1;61(2):124-131. https://doi.org/10.1002/pros.20080
Roberts, Rosebud O ; Jacobson, Debra J. ; Rhodes, Thomas ; Klee, George G. ; Leiber, Michael M. ; Jacobsen, Steven J. / Serum sex hormones and measures of benign prostatic hyperplasia. In: Prostate. 2004 ; Vol. 61, No. 2. pp. 124-131.
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