Serum response factor micromanaging cardiogenesis

Zhivy Niu, Ankang Li, Shu X. Zhang, Robert J. Schwartz

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

Serum response factor (SRF), a cardiac-enriched transcription factor, is required for the appearance of beating sarcomeres in the heart. SRF may also direct the expression of microRNAs (miRs) that inhibit the expression of cardiac regulatory factors. The recent knockout of miR-1-2, an SRF gene target, showed defective heart development, caused in part by the induction of GATA6, Irx4/5, and Hand2, that may alter cardiac morphogenesis, channel activity, and cell cycling. SRF and cofactors play an obligatory role in cardiogenesis, as major determinants of myocyte differentiation not only by regulating the biogenesis of muscle contractile proteins but also by driving the expression of silencer miRNA.

Original languageEnglish (US)
Pages (from-to)618-627
Number of pages10
JournalCurrent Opinion in Cell Biology
Volume19
Issue number6
DOIs
StatePublished - Dec 2007

ASJC Scopus subject areas

  • Cell Biology

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