Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer

Manish Kohli, Ann L. Oberg, Douglas W. Mahoney, Shaun M. Riska, Robert Sherwood, Yuzi Zhang, Roman M. Zenka, Deepak Sahasrabudhe, Rui Qin, Sheng Zhang

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A global serum proteomic analysis was performed using liquid chromatography coupled with tandem mass spectrometry to identify predictive biomarkers in hormone-sensitive prostate cancer patients undergoing androgen deprivation therapy. We identified 47 candidates and then performed network enrichment analysis, which implicated β estradiol, nuclear factor kappa-light-chain enhancer of activated B cells complex, and P38 mitogen-activated protein kinases complex pathways as candidate pathways with potential predictive biomarkers of androgen deprivation.

Original languageEnglish (US)
Pages (from-to)248-253.e7
JournalClinical Genitourinary Cancer
Volume17
Issue number4
DOIs
StatePublished - Aug 2019

Keywords

  • Hormonal therapy
  • Predictive factors
  • Prostate cancer
  • Proteomics
  • Serum

ASJC Scopus subject areas

  • Oncology
  • Urology

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    Kohli, M., Oberg, A. L., Mahoney, D. W., Riska, S. M., Sherwood, R., Zhang, Y., Zenka, R. M., Sahasrabudhe, D., Qin, R., & Zhang, S. (2019). Serum Proteomics on the Basis of Discovery of Predictive Biomarkers of Response to Androgen Deprivation Therapy in Advanced Prostate Cancer. Clinical Genitourinary Cancer, 17(4), 248-253.e7. https://doi.org/10.1016/j.clgc.2019.03.006