Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome

Umer Saleem, Thomas H. Mosley, Iftikhar Jan Kullo

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Objective-: Osteocalcin has been reported to influence insulin secretion in experimental animals. We investigated whether serum osteocalcin was associated with measures of insulin resistance, circulating adipokine levels, and the presence of metabolic syndrome (MetSyn). Methods and Results-: Serum osteocalcin was measured by solid-phase sandwich immunoassay in 1284 blacks (64±9 years; 71% women) and 1209 non-Hispanic whites (59±10 years; 57% women) belonging to hypertensive sibships. MetSyn was defined per Adult Treatment Panel III criteria. The prevalence of MetSyn was 50% in blacks and 49% in non-Hispanic whites. In each ethnic group, after adjustment for age and gender, osteocalcin levels were inversely correlated with body mass index, fasting glucose and insulin, homeostasis model assessment of insulin resistance, triglycerides, and leptin, and positively correlated with adiponectin (P<0.001 for each variable). In multivariable regression analyses that adjusted for age, gender, smoking, serum creatinine, and statin and estrogen use, osteocalcin levels in the highest quartile (compared with the lowest quartile) were associated with a lower odds ratio (OR) of having MetSyn: OR (95% CI) in blacks, 0.33 (0.23 to 0.46); OR in non-Hispanic whites, 0.43 (0.31 to 0.63). Conclusion-: Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of MetSyn, suggesting a novel cross-talk between bone and adipose tissue.

Original languageEnglish (US)
Pages (from-to)1474-1478
Number of pages5
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume30
Issue number7
DOIs
StatePublished - Jul 2010

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Adipokines
Osteocalcin
Insulin Resistance
Serum
Odds Ratio
Insulin
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Adiponectin
Leptin
Immunoassay
Ethnic Groups
Adipose Tissue
Fasting
Creatinine
Estrogens
Triglycerides
Body Mass Index
Homeostasis
Smoking
Regression Analysis

Keywords

  • adiponectin
  • insulin resistance
  • leptin
  • metabolic syndrome
  • osteocalcin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. / Saleem, Umer; Mosley, Thomas H.; Kullo, Iftikhar Jan.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 30, No. 7, 07.2010, p. 1474-1478.

Research output: Contribution to journalArticle

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