Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss

Virgilio G.H. Evidente; John N. Caviness; Charles H. Adler; Katrina A. Gwinn-Hardy; Richard E. Pratley

doi:10.1002/mds.1165

Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss

Virgilio G.H. Evidente, John N. Caviness, Charles H. Adler, Katrina A. Gwinn-Hardy, Richard E. Pratley

Neurology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger, satiety, fullness, and thirst did not differ between groups. However, the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. The results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations.

Original language	English (US)
Pages (from-to)	924-927
Number of pages	4
Journal	Movement Disorders
Volume	16
Issue number	5
DOIs	https://doi.org/10.1002/mds.1165
State	Published - Sep 2001

Keywords

Leptin
Parkinson's disease
Satiety
Weight loss

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.1165

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title = "Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss",

abstract = "We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger, satiety, fullness, and thirst did not differ between groups. However, the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. The results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations.",

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AU - Evidente, Virgilio G.H.

AU - Caviness, John N.

AU - Adler, Charles H.

AU - Gwinn-Hardy, Katrina A.

AU - Pratley, Richard E.

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AB - We compared serum leptin and satiety measures in 18 Parkinson's disease (PD) patients with unintended weight loss (WL) and 18 PD patients whose weight was stable (WS). Mean serum leptin concentrations tended to be lower in WL than WS patients, but this did not reach statistical significance. Body mass index correlated with serum leptin concentrations. Ratings of hunger, satiety, fullness, and thirst did not differ between groups. However, the mean sensation of fullness before meals correlated with serum leptin in the entire cohort of patients, particularly in the WL group. The results indicate that unintended weight loss in PD patients is unlikely to be due to abnormal serum leptin concentrations.

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Serum leptin concentrations and satiety in Parkinson's disease patients with and without weight loss

Abstract

Keywords

ASJC Scopus subject areas

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