Serum immunoreactive melatonin in boys with delayed puberty

H. N. Cohen, I. D. Hay, T. M. Annesley, G. H. Beastall, A. M. Wallace, R. Spooner, J. A. Thomson, P. Eastwold, G. G. Klee

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Serum immunoreactive melatonin was measured in 33 male subjects with delayed puberty, 30 of whom had simple (idiopathic) delayed puberty (SDP) and 3 of whom were GH deficient. The results were compared with a control population of 26 subjects. Significantly elevated values of serum melatonin were demonstrated in both groups of abnormal subjects as compared with the control population (P<0.0001). No significant fall of serum melatonin was noted in the subjects with simple pubertal delay prior to the onset of puberty. However, there was a significant fall of serum melatonin in these subjects between mid and late puberty (P<0.025). The results suggest that whilst melatonin may inhibit puberty, a fall in serum levels is not essential for the commencement of puberty in man.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalClinical Endocrinology
Issue number5
StatePublished - 1982
Externally publishedYes


ASJC Scopus subject areas

  • Endocrinology

Cite this

Cohen, H. N., Hay, I. D., Annesley, T. M., Beastall, G. H., Wallace, A. M., Spooner, R., Thomson, J. A., Eastwold, P., & Klee, G. G. (1982). Serum immunoreactive melatonin in boys with delayed puberty. Clinical Endocrinology, 17(5), 517-521.