Serum immunoreactive melatonin was measured in 33 male subjects with delayed puberty, 30 of whom had simple (idiopathic) delayed puberty (SDP) and 3 of whom were GH deficient. The results were compared with a control population of 26 subjects. Significantly elevated values of serum melatonin were demonstrated in both groups of abnormal subjects as compared with the control population (P<0.0001). No significant fall of serum melatonin was noted in the subjects with simple pubertal delay prior to the onset of puberty. However, there was a significant fall of serum melatonin in these subjects between mid and late puberty (P<0.025). The results suggest that whilst melatonin may inhibit puberty, a fall in serum levels is not essential for the commencement of puberty in man.
|Original language||English (US)|
|Number of pages||5|
|State||Published - 1982|
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