Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias

Guner Hayri Ozsan, Angela Dispenzieri

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalExpert review of clinical immunology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2011

Keywords

  • free light chain
  • immunoglobulin
  • multiple myeloma
  • plasma cell disorders

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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