Abstract
After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 65-73 |
| Number of pages | 9 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2011 |
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Keywords
- free light chain
- immunoglobulin
- multiple myeloma
- plasma cell disorders
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias. / Ozsan, Guner Hayri; Dispenzieri, Angela.
In: Expert Review of Clinical Immunology, Vol. 7, No. 1, 01.2011, p. 65-73.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum free light chain analysis in multiple myeloma and plasma cell dyscrasias
AU - Ozsan, Guner Hayri
AU - Dispenzieri, Angela
PY - 2011/1
Y1 - 2011/1
N2 - After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.
AB - After the development of a reliable method to detect free light chains in serum, several investigations have been conducted to explore their importance in plasma cell dyscrasias (PCD). Detection of monoclonal proteins is very important in the diagnosis and management of PCD, which include a broad spectrum of diseases such as multiple myeloma and also benign, premalignant disorders like monoclonal gammopathy of undetermined significance. The aim of this article is to summarize the recent studies and to highlight the importance of free light chain analysis in the diagnosis of PCD, its prognostic value and role in the management of this group of diseases.
KW - free light chain
KW - immunoglobulin
KW - multiple myeloma
KW - plasma cell disorders
UR - http://www.scopus.com/inward/record.url?scp=78650579306&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650579306&partnerID=8YFLogxK
U2 - 10.1586/eci.10.80
DO - 10.1586/eci.10.80
M3 - Article
C2 - 21162651
AN - SCOPUS:78650579306
VL - 7
SP - 65
EP - 73
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 1
ER -