TY - JOUR
T1 - Serum dopamine-β-hydroxylase
T2 - Decrease after chemical sympathectomy
AU - Weinshilboum, Richard
AU - Axelrod, Julius
PY - 1971
Y1 - 1971
N2 - Dopamine-β-hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine-β-3-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-β-hydroxylase activity arises from sympathetic nerve terminals.
AB - Dopamine-β-hydroxylase is an enzyme that is localized to catecholamine-containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum. Treatment of rats with 6-hydroxydopamine, a drug which destroys sympathetic nerve terminals, leads to a decrease in serum dopamine-β-3-hydroxylase activity. The decrease is not due to an effect on the adrenal medulla or to an increase in circulating inhibitor or inhibitors of enzyme. These data represent evidence that at least a portion of the circulating dopamine-β-hydroxylase activity arises from sympathetic nerve terminals.
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U2 - 10.1126/science.173.4000.931
DO - 10.1126/science.173.4000.931
M3 - Article
C2 - 5572168
AN - SCOPUS:0015209463
SN - 0036-8075
VL - 173
SP - 931
EP - 934
JO - Science
JF - Science
IS - 4000
ER -