To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?
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