Serum antiocular antibodies in patients with juvenile rheumatoid arthritis

J. N. Bloom, M. Ni, T. L. Moore, Thomas Osborn, G. S. Hageman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Although the uveitis associated with juvenile rheumatoid arthritis (JRA) is presumed to have an autoimmune etiology, its pathogenesis is unknown. We utilized immunohistochemical techniques to detect the presence of serum antibodies directed against ocular tissues in these patients. The staining patterns of serum from patients with JRA, with and without uveitis, were compared with normal controls. Antibodies directed against epitopes in iris and ciliary body basement membranes, lens epithelium and fibers, Bruch's membrane, and iris and retinal blood vessels were observed in the sera of several individuals. These staining patterns were statistically more frequent among the pauciarticular and polyarticular JRA patients, with and without uveitis, than either the systemic JRA or normal populations. These results demonstrate the presence of antiocular antibodies in the sera of JRA patients, with and without uveitis. Whether those nonuveitic JRA patients with antiocular antibodies will develop uveitis is unknown at this time.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalJournal of Pediatric Ophthalmology and Strabismus
Volume30
Issue number4
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Juvenile Arthritis
Uveitis
Antibodies
Serum
Iris
Bruch Membrane
Staining and Labeling
Retinal Vessels
Ciliary Body
Basement Membrane
Lenses
Epitopes
Epithelium
Population

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

Cite this

Serum antiocular antibodies in patients with juvenile rheumatoid arthritis. / Bloom, J. N.; Ni, M.; Moore, T. L.; Osborn, Thomas; Hageman, G. S.

In: Journal of Pediatric Ophthalmology and Strabismus, Vol. 30, No. 4, 01.01.1993, p. 243-248.

Research output: Contribution to journalArticle

Bloom, J. N. ; Ni, M. ; Moore, T. L. ; Osborn, Thomas ; Hageman, G. S. / Serum antiocular antibodies in patients with juvenile rheumatoid arthritis. In: Journal of Pediatric Ophthalmology and Strabismus. 1993 ; Vol. 30, No. 4. pp. 243-248.
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