Serum angiotensin converting enzyme activity in evaluation of patients with liver disease

David A. Johnson, Anna Mae Diehl, Maria H. Sjogren, Jeffrey Lazar, Edward L. Cattau, Robert Christian Smallridge

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study was undertaken to evaluate angiotensin converting enzyme activity in patients with liver disease, and to explore its relationship to thyroid function in patients with liver disease. Serum angiotensin converting enzyme activity and thyroid hormone levels, determined in 79 patients with intrahepatic-type liver disease and 18 patients with extrahepatic biliary obstruction, were compared with values in 129 euthyroid controls. Serum angiotensin converting enzyme activity was higher in intrahepatic disease than in extrahepatic obstruction, but statistically significant only for acute intrahepatic disease. In the patients studied, high serum angiotensin converting enzyme activity (22 units/ml or more) virtually excluded extrahepatic biliary obstruction, with a negative predictive value of 94 percent. Low serum angiotensin converting enzyme activity had a positive predictive value for extrahepatic obstruction of only 67 percent. Increased angiotensin converting enzyme activity could not be explained as a function of enhanced thyroid activity. Serum angiotensin converting enzyme activity may be useful in separating patients with intrahepatic liver disease from those with extrahepatic obstruction.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalThe American journal of medicine
Volume83
Issue number2
DOIs
StatePublished - 1987
Externally publishedYes

Fingerprint

Peptidyl-Dipeptidase A
Liver Diseases
Serum
Thyroid Gland
Acute Disease
Thyroid Hormones

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Serum angiotensin converting enzyme activity in evaluation of patients with liver disease. / Johnson, David A.; Mae Diehl, Anna; Sjogren, Maria H.; Lazar, Jeffrey; Cattau, Edward L.; Smallridge, Robert Christian.

In: The American journal of medicine, Vol. 83, No. 2, 1987, p. 256-260.

Research output: Contribution to journalArticle

Johnson, David A. ; Mae Diehl, Anna ; Sjogren, Maria H. ; Lazar, Jeffrey ; Cattau, Edward L. ; Smallridge, Robert Christian. / Serum angiotensin converting enzyme activity in evaluation of patients with liver disease. In: The American journal of medicine. 1987 ; Vol. 83, No. 2. pp. 256-260.
@article{85c2dd83b01f4cfdbc2f2ac18ee57ef6,
title = "Serum angiotensin converting enzyme activity in evaluation of patients with liver disease",
abstract = "This study was undertaken to evaluate angiotensin converting enzyme activity in patients with liver disease, and to explore its relationship to thyroid function in patients with liver disease. Serum angiotensin converting enzyme activity and thyroid hormone levels, determined in 79 patients with intrahepatic-type liver disease and 18 patients with extrahepatic biliary obstruction, were compared with values in 129 euthyroid controls. Serum angiotensin converting enzyme activity was higher in intrahepatic disease than in extrahepatic obstruction, but statistically significant only for acute intrahepatic disease. In the patients studied, high serum angiotensin converting enzyme activity (22 units/ml or more) virtually excluded extrahepatic biliary obstruction, with a negative predictive value of 94 percent. Low serum angiotensin converting enzyme activity had a positive predictive value for extrahepatic obstruction of only 67 percent. Increased angiotensin converting enzyme activity could not be explained as a function of enhanced thyroid activity. Serum angiotensin converting enzyme activity may be useful in separating patients with intrahepatic liver disease from those with extrahepatic obstruction.",
author = "Johnson, {David A.} and {Mae Diehl}, Anna and Sjogren, {Maria H.} and Jeffrey Lazar and Cattau, {Edward L.} and Smallridge, {Robert Christian}",
year = "1987",
doi = "10.1016/0002-9343(87)90694-2",
language = "English (US)",
volume = "83",
pages = "256--260",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Serum angiotensin converting enzyme activity in evaluation of patients with liver disease

AU - Johnson, David A.

AU - Mae Diehl, Anna

AU - Sjogren, Maria H.

AU - Lazar, Jeffrey

AU - Cattau, Edward L.

AU - Smallridge, Robert Christian

PY - 1987

Y1 - 1987

N2 - This study was undertaken to evaluate angiotensin converting enzyme activity in patients with liver disease, and to explore its relationship to thyroid function in patients with liver disease. Serum angiotensin converting enzyme activity and thyroid hormone levels, determined in 79 patients with intrahepatic-type liver disease and 18 patients with extrahepatic biliary obstruction, were compared with values in 129 euthyroid controls. Serum angiotensin converting enzyme activity was higher in intrahepatic disease than in extrahepatic obstruction, but statistically significant only for acute intrahepatic disease. In the patients studied, high serum angiotensin converting enzyme activity (22 units/ml or more) virtually excluded extrahepatic biliary obstruction, with a negative predictive value of 94 percent. Low serum angiotensin converting enzyme activity had a positive predictive value for extrahepatic obstruction of only 67 percent. Increased angiotensin converting enzyme activity could not be explained as a function of enhanced thyroid activity. Serum angiotensin converting enzyme activity may be useful in separating patients with intrahepatic liver disease from those with extrahepatic obstruction.

AB - This study was undertaken to evaluate angiotensin converting enzyme activity in patients with liver disease, and to explore its relationship to thyroid function in patients with liver disease. Serum angiotensin converting enzyme activity and thyroid hormone levels, determined in 79 patients with intrahepatic-type liver disease and 18 patients with extrahepatic biliary obstruction, were compared with values in 129 euthyroid controls. Serum angiotensin converting enzyme activity was higher in intrahepatic disease than in extrahepatic obstruction, but statistically significant only for acute intrahepatic disease. In the patients studied, high serum angiotensin converting enzyme activity (22 units/ml or more) virtually excluded extrahepatic biliary obstruction, with a negative predictive value of 94 percent. Low serum angiotensin converting enzyme activity had a positive predictive value for extrahepatic obstruction of only 67 percent. Increased angiotensin converting enzyme activity could not be explained as a function of enhanced thyroid activity. Serum angiotensin converting enzyme activity may be useful in separating patients with intrahepatic liver disease from those with extrahepatic obstruction.

UR - http://www.scopus.com/inward/record.url?scp=0023634169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023634169&partnerID=8YFLogxK

U2 - 10.1016/0002-9343(87)90694-2

DO - 10.1016/0002-9343(87)90694-2

M3 - Article

VL - 83

SP - 256

EP - 260

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

IS - 2

ER -