Serum amyloid A and P protein genes in familial Mediterranean fever

M. Shohat, T. Shohat, J. I. Rotter, M. Schlesinger, G. M. Petersen, T. Pribyl, G. Sack, A. D. Schwabe, J. R. Korenberg

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Two recent studies have suggested the involvement of serum amyloid A (SAA) and P (APCS) genes in familial Mediterranean fever (MEF). To test the role of SAA and APCS in MEF and MEF-amyloidosis, we studied 17 informative families (15 Armenians, 2 non-Ashkenazi Jews) and 8 MEF patients with amyloidosis using a candidate gene approach. No evidence for any MEF-associated polymorphism was found in any of the 41 Armenian and Jewish MEF patients tested. Our family studies allowed us to rule out tight linkage between SAA and MEF (lod score = -2.16, θ ≤ 0.06). For APCS we found that the allele frequency in the MEF-amyloidosis patients was similar to that in 18 unrelated MEF patients without amyloidosis and their 33 healthy parents. Finally, we excluded close genetic linkage between APCS and MEF at 8.5 cM or less (lod score = -2.2).

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalGenomics
Volume8
Issue number1
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Genetics

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    Shohat, M., Shohat, T., Rotter, J. I., Schlesinger, M., Petersen, G. M., Pribyl, T., Sack, G., Schwabe, A. D., & Korenberg, J. R. (1990). Serum amyloid A and P protein genes in familial Mediterranean fever. Genomics, 8(1), 83-89. https://doi.org/10.1016/0888-7543(90)90228-M