Serum albumin level is a notable profiling factor for non-B, non-C hepatitis virus-related hepatocellular carcinoma: A data-mining analysis

Shingo Yamada, Atsushi Kawaguchi, Takumi Kawaguchi, Nobuyoshi Fukushima, Ryoko Kuromatsu, Shuji Sumie, Akio Takata, Masahito Nakano, Manabu Satani, Tatsuyuki Tonan, Kiminori Fujimoto, Hiroji Shima, Tatsuyuki Kakuma, Takuji Torimura, Michael R. Charlton, Michio Sata

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Aim: Various factors are underlying for the onset of non-B, non-C hepatitis virus-related hepatocellular carcinoma (NBNC-HCC). We aimed to investigate the independent risk factors and profiles associated with NBNC-HCC using a data-mining technique. Methods: We conducted a case-control study and enrolled 223 NBNC-HCC patients and 669 controls from a health checkup database (n=176886). Multivariate analysis, random forest analysis and a decision-tree algorithm were employed to examine the independent risk factors, factors distinguishing between the case and control groups, and to identify profiles for the incidence of NBNC-HCC, respectively. Results: In multivariate analysis, besides γ-glutamyltransferase (GGT) levels and the Brinkman index, albumin level was an independent negative risk factor for the incidence of NBNC-HCC (odds ratio=0.67; 95% confidence interval=0.60-0.70; P<0.0001). In random forest analysis, serum albumin level was the highest-ranked variable for distinguishing between the case and control groups (98 variable importance). A decision-tree algorithm was created for albumin and GGT levels, the aspartate aminotransferase-to-platelet ratio index (APRI) and the Brinkman index. The serum albumin level was selected as the initial split variable, and 82.5% of the subjects with albumin levels of less than 4.01g/dL were found to have NBNC-HCC. Conclusion: Data-mining analysis revealed that serum albumin level is an independent risk factor and the most distinguishable factor associated with the incidence of NBNC-HCC. Furthermore, we created an NBNC-HCC profile consisting of albumin and GGT levels, the APRI and the Brinkman index. This profile could be used in the screening strategy for NBNC-HCC.

Original languageEnglish (US)
Pages (from-to)837-845
Number of pages9
JournalHepatology Research
Volume44
Issue number8
DOIs
StatePublished - Aug 2014

Keywords

  • Lifestyle
  • Metabolism
  • Non-viral-related hepatoma
  • Smoking

ASJC Scopus subject areas

  • Hepatology
  • Infectious Diseases

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    Yamada, S., Kawaguchi, A., Kawaguchi, T., Fukushima, N., Kuromatsu, R., Sumie, S., Takata, A., Nakano, M., Satani, M., Tonan, T., Fujimoto, K., Shima, H., Kakuma, T., Torimura, T., Charlton, M. R., & Sata, M. (2014). Serum albumin level is a notable profiling factor for non-B, non-C hepatitis virus-related hepatocellular carcinoma: A data-mining analysis. Hepatology Research, 44(8), 837-845. https://doi.org/10.1111/hepr.12192