TY - JOUR
T1 - Serum albumin level is a notable profiling factor for non-B, non-C hepatitis virus-related hepatocellular carcinoma
T2 - A data-mining analysis
AU - Yamada, Shingo
AU - Kawaguchi, Atsushi
AU - Kawaguchi, Takumi
AU - Fukushima, Nobuyoshi
AU - Kuromatsu, Ryoko
AU - Sumie, Shuji
AU - Takata, Akio
AU - Nakano, Masahito
AU - Satani, Manabu
AU - Tonan, Tatsuyuki
AU - Fujimoto, Kiminori
AU - Shima, Hiroji
AU - Kakuma, Tatsuyuki
AU - Torimura, Takuji
AU - Charlton, Michael R.
AU - Sata, Michio
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Aim: Various factors are underlying for the onset of non-B, non-C hepatitis virus-related hepatocellular carcinoma (NBNC-HCC). We aimed to investigate the independent risk factors and profiles associated with NBNC-HCC using a data-mining technique. Methods: We conducted a case-control study and enrolled 223 NBNC-HCC patients and 669 controls from a health checkup database (n=176886). Multivariate analysis, random forest analysis and a decision-tree algorithm were employed to examine the independent risk factors, factors distinguishing between the case and control groups, and to identify profiles for the incidence of NBNC-HCC, respectively. Results: In multivariate analysis, besides γ-glutamyltransferase (GGT) levels and the Brinkman index, albumin level was an independent negative risk factor for the incidence of NBNC-HCC (odds ratio=0.67; 95% confidence interval=0.60-0.70; P<0.0001). In random forest analysis, serum albumin level was the highest-ranked variable for distinguishing between the case and control groups (98 variable importance). A decision-tree algorithm was created for albumin and GGT levels, the aspartate aminotransferase-to-platelet ratio index (APRI) and the Brinkman index. The serum albumin level was selected as the initial split variable, and 82.5% of the subjects with albumin levels of less than 4.01g/dL were found to have NBNC-HCC. Conclusion: Data-mining analysis revealed that serum albumin level is an independent risk factor and the most distinguishable factor associated with the incidence of NBNC-HCC. Furthermore, we created an NBNC-HCC profile consisting of albumin and GGT levels, the APRI and the Brinkman index. This profile could be used in the screening strategy for NBNC-HCC.
AB - Aim: Various factors are underlying for the onset of non-B, non-C hepatitis virus-related hepatocellular carcinoma (NBNC-HCC). We aimed to investigate the independent risk factors and profiles associated with NBNC-HCC using a data-mining technique. Methods: We conducted a case-control study and enrolled 223 NBNC-HCC patients and 669 controls from a health checkup database (n=176886). Multivariate analysis, random forest analysis and a decision-tree algorithm were employed to examine the independent risk factors, factors distinguishing between the case and control groups, and to identify profiles for the incidence of NBNC-HCC, respectively. Results: In multivariate analysis, besides γ-glutamyltransferase (GGT) levels and the Brinkman index, albumin level was an independent negative risk factor for the incidence of NBNC-HCC (odds ratio=0.67; 95% confidence interval=0.60-0.70; P<0.0001). In random forest analysis, serum albumin level was the highest-ranked variable for distinguishing between the case and control groups (98 variable importance). A decision-tree algorithm was created for albumin and GGT levels, the aspartate aminotransferase-to-platelet ratio index (APRI) and the Brinkman index. The serum albumin level was selected as the initial split variable, and 82.5% of the subjects with albumin levels of less than 4.01g/dL were found to have NBNC-HCC. Conclusion: Data-mining analysis revealed that serum albumin level is an independent risk factor and the most distinguishable factor associated with the incidence of NBNC-HCC. Furthermore, we created an NBNC-HCC profile consisting of albumin and GGT levels, the APRI and the Brinkman index. This profile could be used in the screening strategy for NBNC-HCC.
KW - Lifestyle
KW - Metabolism
KW - Non-viral-related hepatoma
KW - Smoking
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U2 - 10.1111/hepr.12192
DO - 10.1111/hepr.12192
M3 - Article
AN - SCOPUS:84904763287
SN - 1386-6346
VL - 44
SP - 837
EP - 845
JO - Hepatology Research
JF - Hepatology Research
IS - 8
ER -