Serum 25-hydroxyvitamin D (25[OH]D) concentrations are positively associated with pneumococcal antibody titers (PATs) in subjects with atopy or asthma. Little is known about the association of serum 25(OH)D concentrations and the waning of PATs over time in subjects with or without atopy. This study was designed to determine whether serum 25(OH)D concentrations are associated with waning of PATs and if such relationship is modified by atopic conditions. The study was designed as a prospective cohort study, which followed 20 asthmatic patients and 19 individuals without asthma for an average of 12 months. We measured PATs and serum 25(OH)D concentrations at baseline and at a subsequent follow-up visit. Asthma was ascertained by predetermined criteria. The association between serum 25(OH)D concentrations and PATs was determined by Pearson's correlation coefficient and a least square model. Of the 39 children and adults, 21(53%) were male subjects, all were white, and 6 (15%) were children. There was an overall negative correlation between serum 25(OH)D concentrations and the decrease of PATs during follow-up (r = -0.47; p = 0.004), suggesting that higher 25(OH)D concentrations were associated with a reduction in waning of PATs over time. Controlling for follow-up duration and pneumococcal colonization, these trends were significant among asthmatic patients but not in individuals without asthma. Similar trends were observed for individuals with or without other atopic conditions. Serum 25(OH)D concentrations are inversely associated with the waning of PATs over time, especially individuals with asthma and other atopy conditions. These study findings deserve further investigation.
ASJC Scopus subject areas
- Immunology and Allergy
- Pulmonary and Respiratory Medicine