Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa

Bolni Nagalo, Cyrille Bisseye, Mahamoudou Sanou, Kisito Kienou, Yacouba K. Nebié, Alice Kiba, Honorine Dahourou, Siaka Ouattara, Jean Baptiste Nikiema, Rémy Moret, Jean Didier Zongo, Jacques Simpore

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background and objective The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in Burkina Faso. Methods A retrospective study of blood donors' records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first-time blood donors. Results Of the total of 31405 first-time volunteer blood donors in 2009, 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV, HBV, HCV and syphilis in first-time volunteer donors was 1.8%, 13.4%, 6.3% and 2.1%, respectively. In 3981 repeat donors, the incidence rate was 3270.2, 5874.1 and 6784.6 per 100000 donations for anti-HIV-1, HBsAg and anti-HCV, respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso. Conclusion The relatively high prevalence of viral markers in first-time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalTropical Medicine and International Health
Volume17
Issue number2
DOIs
StatePublished - Feb 1 2012
Externally publishedYes

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Burkina Faso
Western Africa
Seroepidemiologic Studies
Blood Donors
Blood Transfusion
Communicable Diseases
Tissue Donors
Volunteers
Incidence
Syphilis
HIV Seroprevalence
Blood Safety
Africa South of the Sahara
Virus Diseases
Hepatitis B Surface Antigens
Infection
HIV-1
Retrospective Studies
Biomarkers
HIV

Keywords

  • Blood donors
  • HBV
  • HCV
  • HIV
  • Transfusion

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Parasitology

Cite this

Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa. / Nagalo, Bolni; Bisseye, Cyrille; Sanou, Mahamoudou; Kienou, Kisito; Nebié, Yacouba K.; Kiba, Alice; Dahourou, Honorine; Ouattara, Siaka; Nikiema, Jean Baptiste; Moret, Rémy; Zongo, Jean Didier; Simpore, Jacques.

In: Tropical Medicine and International Health, Vol. 17, No. 2, 01.02.2012, p. 247-253.

Research output: Contribution to journalArticle

Nagalo, Bolni ; Bisseye, Cyrille ; Sanou, Mahamoudou ; Kienou, Kisito ; Nebié, Yacouba K. ; Kiba, Alice ; Dahourou, Honorine ; Ouattara, Siaka ; Nikiema, Jean Baptiste ; Moret, Rémy ; Zongo, Jean Didier ; Simpore, Jacques. / Seroprevalence and incidence of transfusion-transmitted infectious diseases among blood donors from regional blood transfusion centres in Burkina Faso, West Africa. In: Tropical Medicine and International Health. 2012 ; Vol. 17, No. 2. pp. 247-253.
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AU - Nagalo, Bolni

AU - Bisseye, Cyrille

AU - Sanou, Mahamoudou

AU - Kienou, Kisito

AU - Nebié, Yacouba K.

AU - Kiba, Alice

AU - Dahourou, Honorine

AU - Ouattara, Siaka

AU - Nikiema, Jean Baptiste

AU - Moret, Rémy

AU - Zongo, Jean Didier

AU - Simpore, Jacques

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N2 - Background and objective The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in Burkina Faso. Methods A retrospective study of blood donors' records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first-time blood donors. Results Of the total of 31405 first-time volunteer blood donors in 2009, 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV, HBV, HCV and syphilis in first-time volunteer donors was 1.8%, 13.4%, 6.3% and 2.1%, respectively. In 3981 repeat donors, the incidence rate was 3270.2, 5874.1 and 6784.6 per 100000 donations for anti-HIV-1, HBsAg and anti-HCV, respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso. Conclusion The relatively high prevalence of viral markers in first-time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation.

AB - Background and objective The high prevalence of numerous transfusion-transmitted infectious diseases such as HIV, HBV, HCV and syphilis in sub-Saharan Africa affects blood safety for transfusion recipients. The aim of this study was to evaluate the prevalence and incidence of transfusion-transmissible infectious diseases among blood donors in Burkina Faso. Methods A retrospective study of blood donors' records from January to December 2009 was conducted. Prevalence and incidence of viral infections were calculated among repeat and first-time blood donors. Results Of the total of 31405 first-time volunteer blood donors in 2009, 24.0% were infected with at least one pathogen and 1.8% had serological evidence of multiple infections. The seroprevalence of HIV, HBV, HCV and syphilis in first-time volunteer donors was 1.8%, 13.4%, 6.3% and 2.1%, respectively. In 3981 repeat donors, the incidence rate was 3270.2, 5874.1 and 6784.6 per 100000 donations for anti-HIV-1, HBsAg and anti-HCV, respectively. These numbers varied significantly according to populations where blood is collected and blood centres in Burkina Faso. Conclusion The relatively high prevalence of viral markers in first-time volunteers and remarkably high incidence of infections in repeat donors raise concerns regarding the safety of these donors and suggest that implementation of NAT might significantly improve the situation.

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KW - HBV

KW - HCV

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KW - Transfusion

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