TY - JOUR
T1 - Serological and biochemical identification of hybrid Ia antigens
AU - Lafuse, W. P.
AU - McCormick, J. F.
AU - David, C. S.
PY - 1980
Y1 - 1980
N2 - Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 x B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD x B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of A(k)-E(k), A(b)-E(d), A(b)-E(k), A(s)-E(d), and A(s)-E(k), whereas Ia.23 can be generated by A(d)-E(d), A(d)-E(k), and A(d)-E(p). Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.
AB - Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 x B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD x B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of A(k)-E(k), A(b)-E(d), A(b)-E(k), A(s)-E(d), and A(s)-E(k), whereas Ia.23 can be generated by A(d)-E(d), A(d)-E(k), and A(d)-E(p). Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.
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U2 - 10.1084/jem.151.3.709
DO - 10.1084/jem.151.3.709
M3 - Article
C2 - 7359084
AN - SCOPUS:0018874513
SN - 0022-1007
VL - 151
SP - 709
EP - 715
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 3
ER -