Serological and biochemical identification of hybrid Ia antigens

W. P. Lafuse, J. F. McCormick, C. S. David

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Ia specificities 22 and 23 were found to be determinants on hybrid Ia molecules by serological and biochemical studies. Lipopolysaccharide-stimulated splenic lymphocytes from (B10 x B10.D2)F1 expressed Ia.22 although both the parents were negative. Similarly [D2.GD x B10.A(5R)]F1 cells expressed Ia.23, whereas D2.GD and B10.A(5R) lacked it. Ia.22 can be generated by gene complementation of A(k)-E(k), A(b)-E(d), A(b)-E(k), A(s)-E(d), and A(s)-E(k), whereas Ia.23 can be generated by A(d)-E(d), A(d)-E(k), and A(d)-E(p). Other possible complementing combinations are under study. The role of Ia.22 and 23 in mixed lymphocyte reactions and immune responses are discussed.

Original languageEnglish (US)
Pages (from-to)709-715
Number of pages7
JournalJournal of Experimental Medicine
Volume151
Issue number3
StatePublished - 1980

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Mixed Lymphocyte Culture Test
Histocompatibility Antigens Class II
Lipopolysaccharides
Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology

Cite this

Lafuse, W. P., McCormick, J. F., & David, C. S. (1980). Serological and biochemical identification of hybrid Ia antigens. Journal of Experimental Medicine, 151(3), 709-715.

Serological and biochemical identification of hybrid Ia antigens. / Lafuse, W. P.; McCormick, J. F.; David, C. S.

In: Journal of Experimental Medicine, Vol. 151, No. 3, 1980, p. 709-715.

Research output: Contribution to journalArticle

Lafuse, WP, McCormick, JF & David, CS 1980, 'Serological and biochemical identification of hybrid Ia antigens', Journal of Experimental Medicine, vol. 151, no. 3, pp. 709-715.
Lafuse, W. P. ; McCormick, J. F. ; David, C. S. / Serological and biochemical identification of hybrid Ia antigens. In: Journal of Experimental Medicine. 1980 ; Vol. 151, No. 3. pp. 709-715.
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