Serologic and biochemical studies of the Ia system of the mouse H 2 gene complex. Further evidence for an I C subregion

C. S. David, S. E. Cullen, D. B. Murphy

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Abstract

Three antisera were made against B10.A(5R) tissues to show the presence of an I C(d) subregion in that strain: 1) B10 anti B10.A(5R) [anti D(d), I C(d)]; 2) (B10 x C3H.OL) F1 anti B10.A(5R) [anti D(d)]; 3) (B10 x HTI)F1 anti B10.A(5R) [anti I C(d)]. Serologic analysis of the antisera clearly showed the presence of an I(d) segment in B10.A(5R) and provided further evidence for the existence of a new I C subregion. These anti I C(d) sera define the Ia.7 specificity and analysis of several recombinants map Ia.7 within the I C subregion. Ia.7 is present in I C(k), I C(d) and I(p) strains. Biochemical analysis showed that the Ia.7 molecule has a molecular weight of 31,000 and is distinct from the 46,000 m.w. H 2 K or D molecules. The possible roles of the I C region in immune response, mixed lymphocyte reaction, and graft vs host reaction are discussed.

Original languageEnglish (US)
Pages (from-to)1205-1209
Number of pages5
JournalJournal of Immunology
Volume114
Issue number4
StatePublished - Dec 1 1975

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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