TY - JOUR
T1 - Series on pharmacology in practice. I. Drugs that alter mood. II. Lithium
AU - Rosenbaum, A. H.
AU - Maruta, T.
AU - Richelson, E.
PY - 1979
Y1 - 1979
N2 - In the last two decades, there has been rapid progress in the pharmacologic treatment of affective disorders. In Part 1 of this review, drugs mainly used for depression (tricyclic antidepressants and monosamine oxidase inhibitors) were discussed. Here, lithium carbonate, the most effective drug for manic-depressive illness (bipolar depression) is the focus. Its indications, mode of action, pharmacokinetics, dosage, and side effects are discussed. A section on drug interactions with lithium deals with the combination effect of lithium used with antidepressant and other psychotropic agents.
AB - In the last two decades, there has been rapid progress in the pharmacologic treatment of affective disorders. In Part 1 of this review, drugs mainly used for depression (tricyclic antidepressants and monosamine oxidase inhibitors) were discussed. Here, lithium carbonate, the most effective drug for manic-depressive illness (bipolar depression) is the focus. Its indications, mode of action, pharmacokinetics, dosage, and side effects are discussed. A section on drug interactions with lithium deals with the combination effect of lithium used with antidepressant and other psychotropic agents.
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M3 - Article
C2 - 449409
AN - SCOPUS:0018772153
SN - 0025-6196
VL - 54
SP - 401
EP - 407
JO - Mayo Clinic proceedings
JF - Mayo Clinic proceedings
IS - 6
ER -