In the last two decades, there has been rapid progress in the pharmacologic treatment of affective disorders. In Part 1 of this review, drugs mainly used for depression (tricyclic antidepressants and monosamine oxidase inhibitors) were discussed. Here, lithium carbonate, the most effective drug for manic-depressive illness (bipolar depression) is the focus. Its indications, mode of action, pharmacokinetics, dosage, and side effects are discussed. A section on drug interactions with lithium deals with the combination effect of lithium used with antidepressant and other psychotropic agents.
|Original language||English (US)|
|Number of pages||7|
|Journal||Mayo Clinic Proceedings|
|State||Published - 1979|
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