Septic arthritis in males with haemophilia

Aneel Arjun Ashrani, N. S. Key, J. Michael Soucie, N. Duffy, A. Forsyth, S. Geraghty

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We used data collected as part of the Universal Data Collection (UDC) surveillance project in haemophilia treatment centers (HTC) to study the incidence, risk factors and impact of septic arthritis among males with haemophilia. Patients participating in UDC on two or more occasions were included. Cases were defined as patients with documented joint infection. Characteristics of the cases were compared with those of haemophilia patients without infection. Among the 8026 eligible patients with 36015 person-years of follow-up, 30 (0.37%) had a documented joint infection (incidence rate 83 per 100000 person-years). In a logistic regression model, only increasing age (OR=6.1 for age ≥30), race/ ethnicity other than white (OR=3.9), presence of inhibitor (OR=3.9), invasive procedure in the past year (OR=2.7) and presence of one or more target joints (OR=3.2) remained statistically significant. Central venous access devices use and hepatitis C virus and HIV infection were not associated with septic arthritis risk after adjusting for potential confounders. Study limitations include possible underestimation of septic arthritis rate in this population and its retrospective design. We conclude that septic arthritis is an uncommon complication of haemophilia occurring primarily in joints most affected by bleeding and reparative surgical interventions.

Original languageEnglish (US)
Pages (from-to)494-503
Number of pages10
JournalHaemophilia
Volume14
Issue number3
DOIs
StatePublished - May 2008

Fingerprint

Infectious Arthritis
Hemophilia A
Joints
Infection
Logistic Models
Virus Diseases
Hepacivirus
HIV Infections
Cohort Studies
Hemorrhage
Equipment and Supplies
Incidence
Population
Therapeutics

Keywords

  • Arthropathy
  • Epidemiology
  • Haemophilia
  • Infectious arthritis
  • Joint disease

ASJC Scopus subject areas

  • Hematology

Cite this

Ashrani, A. A., Key, N. S., Michael Soucie, J., Duffy, N., Forsyth, A., & Geraghty, S. (2008). Septic arthritis in males with haemophilia. Haemophilia, 14(3), 494-503. https://doi.org/10.1111/j.1365-2516.2008.01662.x

Septic arthritis in males with haemophilia. / Ashrani, Aneel Arjun; Key, N. S.; Michael Soucie, J.; Duffy, N.; Forsyth, A.; Geraghty, S.

In: Haemophilia, Vol. 14, No. 3, 05.2008, p. 494-503.

Research output: Contribution to journalArticle

Ashrani, AA, Key, NS, Michael Soucie, J, Duffy, N, Forsyth, A & Geraghty, S 2008, 'Septic arthritis in males with haemophilia', Haemophilia, vol. 14, no. 3, pp. 494-503. https://doi.org/10.1111/j.1365-2516.2008.01662.x
Ashrani AA, Key NS, Michael Soucie J, Duffy N, Forsyth A, Geraghty S. Septic arthritis in males with haemophilia. Haemophilia. 2008 May;14(3):494-503. https://doi.org/10.1111/j.1365-2516.2008.01662.x
Ashrani, Aneel Arjun ; Key, N. S. ; Michael Soucie, J. ; Duffy, N. ; Forsyth, A. ; Geraghty, S. / Septic arthritis in males with haemophilia. In: Haemophilia. 2008 ; Vol. 14, No. 3. pp. 494-503.
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