Septal myectomy after failed alcohol ablation: Does previous percutaneous intervention compromise outcomes of myectomy?

Eduard Quintana, Anna Sabate-Rotes, Joseph Maleszewski, Steve R. Ommen, Rick A. Nishimura, Joseph A. Dearani, Hartzell V Schaff

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

OBJECTIVE: The impact of prior alcohol septal ablation in patients who require septal myectomy for hypertrophic obstructive cardiomyopathy is unknown.

METHODS: Thirty-one patients with unsuccessful alcohol septal ablation who underwent septal myectomy were matched 1:2 to patients having had a myectomy as the only invasive procedure for hypertrophic obstructive cardiomyopathy. Study outcomes were cardiac death, advanced heart failure, and appropriate implantable cardioverter defibrillator discharge. The results of surgery, echocardiograms, and pathology specimens were compared between groups.

RESULTS: Patients with previous alcohol septal ablation had increased diastolic dysfunction in preoperative echocardiography, as well as more implantable cardioverter defibrillators implanted (32% vs 11%, P = .01), more arrhythmias in preoperative Holter monitoring (43% vs 13%, P = .02), and a higher incidence of postoperative complete heart block (19.4% vs 1.6%, P < .01). Two patients died early postoperatively in the prior alcohol septal ablation group, and no patients died in the primary myectomy group. One patient in each group had an implantable cardioverter defibrillator (P = .52). At a mean follow-up of 3.2 years, 7 of 31 patients and 6 of 62 patients progressed to advanced heart failure in the prior alcohol septal ablation group and the primary myectomy group, respectively (P = .1) Histopathologic analysis demonstrated greater interstitial (70% vs 26%, P < .01) and endocardial fibrosis (87% vs 67%, P = .04) in the alcohol septal ablation group.

CONCLUSIONS: Patients with prior alcohol septal ablation undergoing surgical septal myectomy may have an increased risk of cardiac death, advanced heart failure, and implantable cardioverter defibrillator discharges. This supports septal myectomy as the preferred treatment for septal reduction therapy, avoiding scarring and diastolic dysfunction inherent to alcohol septal ablation.

Original languageEnglish (US)
Pages (from-to)159-167
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Volume150
Issue number1
DOIs
StatePublished - Jul 1 2015

Fingerprint

Alcohols
Implantable Defibrillators
Heart Failure
Hypertrophic Cardiomyopathy
Ambulatory Electrocardiography
Heart Block
Cicatrix
Echocardiography
Cardiac Arrhythmias
Fibrosis
Outcome Assessment (Health Care)
Pathology
Incidence
Therapeutics

Keywords

  • Hypertrophic obstructive cardiomyopathy
  • septal alcohol ablation
  • septal myectomy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Septal myectomy after failed alcohol ablation : Does previous percutaneous intervention compromise outcomes of myectomy? / Quintana, Eduard; Sabate-Rotes, Anna; Maleszewski, Joseph; Ommen, Steve R.; Nishimura, Rick A.; Dearani, Joseph A.; Schaff, Hartzell V.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 150, No. 1, 01.07.2015, p. 159-167.

Research output: Contribution to journalArticle

Quintana, Eduard ; Sabate-Rotes, Anna ; Maleszewski, Joseph ; Ommen, Steve R. ; Nishimura, Rick A. ; Dearani, Joseph A. ; Schaff, Hartzell V. / Septal myectomy after failed alcohol ablation : Does previous percutaneous intervention compromise outcomes of myectomy?. In: Journal of Thoracic and Cardiovascular Surgery. 2015 ; Vol. 150, No. 1. pp. 159-167.
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abstract = "OBJECTIVE: The impact of prior alcohol septal ablation in patients who require septal myectomy for hypertrophic obstructive cardiomyopathy is unknown.METHODS: Thirty-one patients with unsuccessful alcohol septal ablation who underwent septal myectomy were matched 1:2 to patients having had a myectomy as the only invasive procedure for hypertrophic obstructive cardiomyopathy. Study outcomes were cardiac death, advanced heart failure, and appropriate implantable cardioverter defibrillator discharge. The results of surgery, echocardiograms, and pathology specimens were compared between groups.RESULTS: Patients with previous alcohol septal ablation had increased diastolic dysfunction in preoperative echocardiography, as well as more implantable cardioverter defibrillators implanted (32{\%} vs 11{\%}, P = .01), more arrhythmias in preoperative Holter monitoring (43{\%} vs 13{\%}, P = .02), and a higher incidence of postoperative complete heart block (19.4{\%} vs 1.6{\%}, P < .01). Two patients died early postoperatively in the prior alcohol septal ablation group, and no patients died in the primary myectomy group. One patient in each group had an implantable cardioverter defibrillator (P = .52). At a mean follow-up of 3.2 years, 7 of 31 patients and 6 of 62 patients progressed to advanced heart failure in the prior alcohol septal ablation group and the primary myectomy group, respectively (P = .1) Histopathologic analysis demonstrated greater interstitial (70{\%} vs 26{\%}, P < .01) and endocardial fibrosis (87{\%} vs 67{\%}, P = .04) in the alcohol septal ablation group.CONCLUSIONS: Patients with prior alcohol septal ablation undergoing surgical septal myectomy may have an increased risk of cardiac death, advanced heart failure, and implantable cardioverter defibrillator discharges. This supports septal myectomy as the preferred treatment for septal reduction therapy, avoiding scarring and diastolic dysfunction inherent to alcohol septal ablation.",
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T2 - Does previous percutaneous intervention compromise outcomes of myectomy?

AU - Quintana, Eduard

AU - Sabate-Rotes, Anna

AU - Maleszewski, Joseph

AU - Ommen, Steve R.

AU - Nishimura, Rick A.

AU - Dearani, Joseph A.

AU - Schaff, Hartzell V

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N2 - OBJECTIVE: The impact of prior alcohol septal ablation in patients who require septal myectomy for hypertrophic obstructive cardiomyopathy is unknown.METHODS: Thirty-one patients with unsuccessful alcohol septal ablation who underwent septal myectomy were matched 1:2 to patients having had a myectomy as the only invasive procedure for hypertrophic obstructive cardiomyopathy. Study outcomes were cardiac death, advanced heart failure, and appropriate implantable cardioverter defibrillator discharge. The results of surgery, echocardiograms, and pathology specimens were compared between groups.RESULTS: Patients with previous alcohol septal ablation had increased diastolic dysfunction in preoperative echocardiography, as well as more implantable cardioverter defibrillators implanted (32% vs 11%, P = .01), more arrhythmias in preoperative Holter monitoring (43% vs 13%, P = .02), and a higher incidence of postoperative complete heart block (19.4% vs 1.6%, P < .01). Two patients died early postoperatively in the prior alcohol septal ablation group, and no patients died in the primary myectomy group. One patient in each group had an implantable cardioverter defibrillator (P = .52). At a mean follow-up of 3.2 years, 7 of 31 patients and 6 of 62 patients progressed to advanced heart failure in the prior alcohol septal ablation group and the primary myectomy group, respectively (P = .1) Histopathologic analysis demonstrated greater interstitial (70% vs 26%, P < .01) and endocardial fibrosis (87% vs 67%, P = .04) in the alcohol septal ablation group.CONCLUSIONS: Patients with prior alcohol septal ablation undergoing surgical septal myectomy may have an increased risk of cardiac death, advanced heart failure, and implantable cardioverter defibrillator discharges. This supports septal myectomy as the preferred treatment for septal reduction therapy, avoiding scarring and diastolic dysfunction inherent to alcohol septal ablation.

AB - OBJECTIVE: The impact of prior alcohol septal ablation in patients who require septal myectomy for hypertrophic obstructive cardiomyopathy is unknown.METHODS: Thirty-one patients with unsuccessful alcohol septal ablation who underwent septal myectomy were matched 1:2 to patients having had a myectomy as the only invasive procedure for hypertrophic obstructive cardiomyopathy. Study outcomes were cardiac death, advanced heart failure, and appropriate implantable cardioverter defibrillator discharge. The results of surgery, echocardiograms, and pathology specimens were compared between groups.RESULTS: Patients with previous alcohol septal ablation had increased diastolic dysfunction in preoperative echocardiography, as well as more implantable cardioverter defibrillators implanted (32% vs 11%, P = .01), more arrhythmias in preoperative Holter monitoring (43% vs 13%, P = .02), and a higher incidence of postoperative complete heart block (19.4% vs 1.6%, P < .01). Two patients died early postoperatively in the prior alcohol septal ablation group, and no patients died in the primary myectomy group. One patient in each group had an implantable cardioverter defibrillator (P = .52). At a mean follow-up of 3.2 years, 7 of 31 patients and 6 of 62 patients progressed to advanced heart failure in the prior alcohol septal ablation group and the primary myectomy group, respectively (P = .1) Histopathologic analysis demonstrated greater interstitial (70% vs 26%, P < .01) and endocardial fibrosis (87% vs 67%, P = .04) in the alcohol septal ablation group.CONCLUSIONS: Patients with prior alcohol septal ablation undergoing surgical septal myectomy may have an increased risk of cardiac death, advanced heart failure, and implantable cardioverter defibrillator discharges. This supports septal myectomy as the preferred treatment for septal reduction therapy, avoiding scarring and diastolic dysfunction inherent to alcohol septal ablation.

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