Sepsis: Clinical dilemmas

Michael J. Murray

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sepsis, manifested by systemic inflammatory response syndrome (SIRS), septic shock and multiple organ dysfunction syndrome (MODS), remains the leading cause of morbidity and mortality in critically ill patients. Despite advances and our knowledge of sepsis, there remain clinical dilemmas that impact how we treat patients. These clinical dilemmas include hypotension, cardiac dysfunction and altered oxygen consumption. There is increasing recognition that treatment of these problems does not necessarily improve outcome. As we improve our understanding of sepsis, there is increased recognition that improvement in morbidity and survival will come not only from treating the manifestations of sepsis but also the endogenous mediators responsible for the development of these clinically important conditions. This manuscript discusses the clinical dilemmas associated with sepsis, current therapy and future directions for managing sepsis.

Original languageEnglish (US)
Pages (from-to)485-491
Number of pages7
JournalYale Journal of Biology and Medicine
Volume71
Issue number6
StatePublished - Nov 1998

Fingerprint

Sepsis
Oxygen
Morbidity
Systemic Inflammatory Response Syndrome
Multiple Organ Failure
Septic Shock
Critical Illness
Oxygen Consumption
Hypotension
Direction compound
Survival
Mortality
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Murray, M. J. (1998). Sepsis: Clinical dilemmas. Yale Journal of Biology and Medicine, 71(6), 485-491.

Sepsis : Clinical dilemmas. / Murray, Michael J.

In: Yale Journal of Biology and Medicine, Vol. 71, No. 6, 11.1998, p. 485-491.

Research output: Contribution to journalArticle

Murray, MJ 1998, 'Sepsis: Clinical dilemmas', Yale Journal of Biology and Medicine, vol. 71, no. 6, pp. 485-491.
Murray, Michael J. / Sepsis : Clinical dilemmas. In: Yale Journal of Biology and Medicine. 1998 ; Vol. 71, No. 6. pp. 485-491.
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