Sentinel lymph node biopsy with metastasis: Can axillary dissection be avoided in some patients with breast cancer?

Carol Reynolds, Rosemarie Mick, John H. Donohue, Clive S. Grant, David R. Farley, Linda S. Callans, Susan G. Orel, Gary L. Keeney, Thomas J. Lawton, Brian J. Czerniecki

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287 Scopus citations

Abstract

Purpose: Recent studies have suggested that the sentinel lymph node (SLN) biopsy is an accurate alternative staging procedure for women with breast cancer. The goal of this study was to identify a subset of breast cancer patients in whom metastatic disease was confined only to the SLN. Materials and Methods: From two institutions, we recruited 222 women with breast cancer for SLN biopsy. A SLN biopsy was performed in each patient, followed by an axillary dissection in 182 patients. Histologic and immunohistochemical cytokeratin stains were used on all SLNs. Results: The SLN was identified in 220 (97.8%) of the 225 biopsies. Evidence of metastatic breast cancer in the SLN was found in 60 (27.0%) of the 222 patients. Of these patients, 32 (53.3%) had evidence of tumor in the SLN only. By multivariate analysis, two factors were found to be significantly associated with a higher likelihood of tumor involvement in the non-SLNs: primary tumor size larger than 2.0 cm (P = .0004) and macrometastasis (> 2.0 mm) in the SLN (P = .002). Additional analysis revealed that none (0%; 95% confidence interval, 0% to 18.5%) of the 18 patients with primary tumors ≤ 2.0 cm and micrometastasis to the SLN had remaining axillary lymph node involvement. Conclusion: The primary tumor size and metastasis size in the SLN care independent factors in predicting the incidence of tumor in the non-SLNs. Therefore, the SLN biopsy alone may be adequate for staging and/or therapy decision making in patients with primary breast tumors ≤ 2.0 cm and micrometastasis in the SLN.

Original languageEnglish (US)
Pages (from-to)1720-1726
Number of pages7
JournalJournal of Clinical Oncology
Volume17
Issue number6
DOIs
StatePublished - Jun 1999

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Reynolds, C., Mick, R., Donohue, J. H., Grant, C. S., Farley, D. R., Callans, L. S., Orel, S. G., Keeney, G. L., Lawton, T. J., & Czerniecki, B. J. (1999). Sentinel lymph node biopsy with metastasis: Can axillary dissection be avoided in some patients with breast cancer? Journal of Clinical Oncology, 17(6), 1720-1726. https://doi.org/10.1200/jco.1999.17.6.1720