Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex

S. M. Sampson, C. Shaw, M. Wilkinson, D. D. Rasmusson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The characteristics and distribution of muscarinic acetylcholine (mACh) receptor binding in primary somatosensory (SI) cortex and the caudate nucleus of raccoons were studied using [3H]-QNB, a muscarinic antagonist. The binding characteristics were similar to reported values in rat and cat. Autoradiographs produced from tissue sections labeled with [3H]-QNB showed the distribution of mACh receptors in the forebrain of the raccoon. [3H]-QNB binding was highest in cerebral cortex, neostriatum and hippocampus. Within SI cortex, binding was high in layers I-III and VI and relatively low in layers IV and V. Autoradiographs obtained from animals that had undergone peripheral deafferentation of part of the forepaw revealed no changes in [3H]-QNB binding in the affected cortical region during the time that physiological reorganization is known to occur.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
JournalBrain Research Bulletin
Volume20
Issue number5
DOIs
StatePublished - 1988
Externally publishedYes

Fingerprint

Raccoons
Somatosensory Cortex
Muscarinic Receptors
Neostriatum
Muscarinic Antagonists
Caudate Nucleus
Prosencephalon
Cerebral Cortex
Hippocampus
Cats

Keywords

  • Deafferentation
  • In vitro autoradiography
  • Muscarinic cholinergic receptors
  • Raccoon
  • Somatosensory cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex. / Sampson, S. M.; Shaw, C.; Wilkinson, M.; Rasmusson, D. D.

In: Brain Research Bulletin, Vol. 20, No. 5, 1988, p. 597-601.

Research output: Contribution to journalArticle

Sampson, S. M. ; Shaw, C. ; Wilkinson, M. ; Rasmusson, D. D. / Sensory deafferentation fails to modify muscarinic receptor binding in raccoon somatosensory cortex. In: Brain Research Bulletin. 1988 ; Vol. 20, No. 5. pp. 597-601.
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