TY - JOUR
T1 - Sensitivity of Mice to Benzo(a)pyrene Skin Cancer following Acclimation to Cool and Warm Temperature
AU - Weiss, Harold S.
AU - Pitt, Joseph F.
AU - Kerr, Kirklyn M.
AU - Hakaim, Albert G.
AU - Weisbrode, Steven E.
AU - Daniel, F. Bernard
N1 - Funding Information:
Aided in part by NIOSH Contracts 210-0132 and 210-78-0030 and EPA Grant CR807342-01-0. Presented in part at 1979 FASEB Meeting (Fed. Proc. 38(3): 1450, 1979).
PY - 1981/5
Y1 - 1981/5
N2 - Skin tumorigenesis induced by benzo(a)pyrene (BaP) in male C3H/HeJ mice was accelerated in a cool (Ta = 16°) and inhibited in a warm (Ta = 32°) environment, compared to the normal Ta = 23°. For example, repetitive, topical application of 0.2 mg BaP/week in 0.08 toluene resulted in (i) the mean tumor appearance time occurring 4-5 weeks earlier in cool and 2-3 weeks later in warm compared with the 21-22 weeks average in normal Ta; (ii) the average number of tumors per mouse increasing twice as fast in cool as in warm Ta; and (iii) shortened survival in cool, lengthened in warm. There were few metastases to internal organs at any temperature. Once initiated, tumors progressed similarly in all Ta's to squamous cell carcinomas. Cool and warm Ta per se had little effect on spontaneous tumors, survival, body weight, rectal temperature, or hair growth. However, skin temperature was 1-2° lower in cool and 1-2° higher in warm Ta than the normal 32-33°. Physiological adaptation was particularly evident in the 66% average higher food intake in cool and 63% lower in warm Ta. These results may help in defining environmental risks in cancer, in increasing the efficiency of cancer screening trials, and in exploring physiological modifiers of carcinogenesis.
AB - Skin tumorigenesis induced by benzo(a)pyrene (BaP) in male C3H/HeJ mice was accelerated in a cool (Ta = 16°) and inhibited in a warm (Ta = 32°) environment, compared to the normal Ta = 23°. For example, repetitive, topical application of 0.2 mg BaP/week in 0.08 toluene resulted in (i) the mean tumor appearance time occurring 4-5 weeks earlier in cool and 2-3 weeks later in warm compared with the 21-22 weeks average in normal Ta; (ii) the average number of tumors per mouse increasing twice as fast in cool as in warm Ta; and (iii) shortened survival in cool, lengthened in warm. There were few metastases to internal organs at any temperature. Once initiated, tumors progressed similarly in all Ta's to squamous cell carcinomas. Cool and warm Ta per se had little effect on spontaneous tumors, survival, body weight, rectal temperature, or hair growth. However, skin temperature was 1-2° lower in cool and 1-2° higher in warm Ta than the normal 32-33°. Physiological adaptation was particularly evident in the 66% average higher food intake in cool and 63% lower in warm Ta. These results may help in defining environmental risks in cancer, in increasing the efficiency of cancer screening trials, and in exploring physiological modifiers of carcinogenesis.
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U2 - 10.3181/00379727-167-41136
DO - 10.3181/00379727-167-41136
M3 - Article
C2 - 7232405
AN - SCOPUS:0019830326
SN - 0037-9727
VL - 167
SP - 122
EP - 128
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 1
ER -