Senescent cells: An emerging target for diseases of ageing

Bennett G. Childs, Martina Gluscevic, Darren J. Baker, Remi Martin Laberge, Dan Marquess, Jamie Dananberg, Jan M. Van Deursen

Research output: Contribution to journalReview article

239 Scopus citations

Abstract

Chronological age represents the single greatest risk factor for human disease. One plausible explanation for this correlation is that mechanisms that drive ageing might also promote age-related diseases. Cellular senescence, which is a permanent state of cell cycle arrest induced by cellular stress, has recently emerged as a fundamental ageing mechanism that also contributes to diseases of late life, including cancer, atherosclerosis and osteoarthritis. Therapeutic strategies that safely interfere with the detrimental effects of cellular senescence, such as the selective elimination of senescent cells (SNCs) or the disruption of the SNC secretome, are gaining significant attention, with several programmes now nearing human clinical studies.

Original languageEnglish (US)
Pages (from-to)718-735
Number of pages18
JournalNature Reviews Drug Discovery
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2017

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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