Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self- and/or informant-rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [<sup>18</sup>F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.

Original languageEnglish (US)
Article number1918
Pages (from-to)1080-1089
Number of pages10
JournalAlzheimer's and Dementia
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2015

Fingerprint

Alzheimer Disease
Aptitude
Amyloid
Positron-Emission Tomography
Self Report
Cognition
Atrophy
Cerebrospinal Fluid
Disease Progression
Brain
Cognitive Dysfunction

Keywords

  • ADNI
  • Alzheimer's disease
  • Biomarkers
  • Daily functioning
  • Dementia
  • Everyday function
  • Informant-report
  • Instrumental activities of daily living
  • Mild cognitive impairment (MCI)
  • Self-report

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. / Alzheimer's Disease Neuroimaging Initiative.

In: Alzheimer's and Dementia, Vol. 11, No. 9, 1918, 01.09.2015, p. 1080-1089.

Research output: Contribution to journalArticle

Alzheimer's Disease Neuroimaging Initiative. / Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease. In: Alzheimer's and Dementia. 2015 ; Vol. 11, No. 9. pp. 1080-1089.
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