Self-monitoring of tear glucose: The development of a tear based glucose sensor as an alternative to self-monitoring of blood glucose

Jeffrey T. La Belle, Anngela Adams, Chi En Lin, Erica Engelschall, Breanna Pratt, Curtiss B. Cook

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Tear glucose sensing for diabetes management has long been sought as an alternative to more invasive self-monitoring of blood glucose (SMBG). However, tear glucose sensors were known to have limitations, including correlation issues with blood glucose due to low sample volume, low concentration of glucose in the tear fluid, and evaporation of the tear sample. An engineering design approach to solve these problems led to the development of an integrated device capable of collecting the tear sample from the ocular surface with little to no stress on the eye, with an extremely low limit of detection, broad dynamic range, and rapid detection and analysis of sample. Here we present the development of a prototypical self-monitoring of tear glucose (SMTG) sensor, summarizing bench studies on the enzymes and their specificity, the development of the fluid capture device and its manufacture and performance and results of system testing in an animal study where safety, lag time and tear glucose to blood glucose correlation were assessed.

Original languageEnglish (US)
Pages (from-to)9197-9204
Number of pages8
JournalChemical Communications
Volume52
Issue number59
DOIs
StatePublished - 2016

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Glucose sensors
Glucose
Blood Glucose
Blood
Monitoring
Fluids
Medical problems
Evaporation
Animals
Testing
Enzymes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Self-monitoring of tear glucose : The development of a tear based glucose sensor as an alternative to self-monitoring of blood glucose. / La Belle, Jeffrey T.; Adams, Anngela; Lin, Chi En; Engelschall, Erica; Pratt, Breanna; Cook, Curtiss B.

In: Chemical Communications, Vol. 52, No. 59, 2016, p. 9197-9204.

Research output: Contribution to journalArticle

La Belle, Jeffrey T. ; Adams, Anngela ; Lin, Chi En ; Engelschall, Erica ; Pratt, Breanna ; Cook, Curtiss B. / Self-monitoring of tear glucose : The development of a tear based glucose sensor as an alternative to self-monitoring of blood glucose. In: Chemical Communications. 2016 ; Vol. 52, No. 59. pp. 9197-9204.
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