TY - JOUR
T1 - Self-Folded Hydrogel Tubes for Implantable Muscular Tissue Scaffolds
AU - Vannozzi, Lorenzo
AU - Yasa, Immihan Ceren
AU - Ceylan, Hakan
AU - Menciassi, Arianna
AU - Ricotti, Leonardo
AU - Sitti, Metin
N1 - Funding Information:
L.V. and I.C.Y. contributed equally to this work. The authors acknowledge funding from the Max Planck Society and the Max Planck ETH Center for Learning Systems. This work was partly supported by the M2Neural project (multifunctional materials for advanced neural interfaces) funded in the FP7 M-ERA.NET Transnational Framework. The authors would like to thank Joshua Giltinan for magnetic field strength measurement and Oncay Yasa for his fruitful discussions on the manuscript.
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/4
Y1 - 2018/4
N2 - Programming materials with tunable physical and chemical interactions among its components pave the way of generating 3D functional active microsystems with various potential applications in tissue engineering, drug delivery, and soft robotics. Here, the development of a recapitulated fascicle-like implantable muscle construct by programmed self-folding of poly(ethylene glycol) diacrylate hydrogels is reported. The system comprises two stacked layers, each with differential swelling degrees, stiffnesses, and thicknesses in 2D, which folds into a 3D tube together. Inside the tubes, muscle cell adhesion and their spatial alignment are controlled. Both skeletal and cardiac muscle cells also exhibit high viability, and cardiac myocytes preserve their contractile function over the course of 7 d. Integration of biological cells with smart, shape-changing materials could give rise to the development of new cellular constructs for hierarchical tissue assembly, drug testing platforms, and biohybrid actuators that can perform sophisticated tasks.
AB - Programming materials with tunable physical and chemical interactions among its components pave the way of generating 3D functional active microsystems with various potential applications in tissue engineering, drug delivery, and soft robotics. Here, the development of a recapitulated fascicle-like implantable muscle construct by programmed self-folding of poly(ethylene glycol) diacrylate hydrogels is reported. The system comprises two stacked layers, each with differential swelling degrees, stiffnesses, and thicknesses in 2D, which folds into a 3D tube together. Inside the tubes, muscle cell adhesion and their spatial alignment are controlled. Both skeletal and cardiac muscle cells also exhibit high viability, and cardiac myocytes preserve their contractile function over the course of 7 d. Integration of biological cells with smart, shape-changing materials could give rise to the development of new cellular constructs for hierarchical tissue assembly, drug testing platforms, and biohybrid actuators that can perform sophisticated tasks.
KW - biohybrid
KW - biomaterials
KW - hydrogel
KW - self-folding
KW - synthetic muscle tissue
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U2 - 10.1002/mabi.201700377
DO - 10.1002/mabi.201700377
M3 - Article
C2 - 29537714
AN - SCOPUS:85045517024
SN - 1616-5187
VL - 18
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 4
M1 - 1700377
ER -