Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart

E. W. Larson, M. A. Pfenning, E. Richelson

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Seven antimuscarinic compounds, used mostly for the treatment of extrapyramidal problems, were tested in vitro in radioligand binding assays for evidence of selectivity for two different pharmacological subtypes of the human muscarinic receptor, M1, a predominant form in brain, and M2, a predominant form in heart. Although biperiden, scopolamine, procyclidine, and benztropine showed significant selectivity in the in vitro assays, it is likely that in clinical practice biperiden would be the drug of choice to avoid any antimuscarinic effects on the heart.

Original languageEnglish (US)
Pages (from-to)162-165
Number of pages4
JournalPsychopharmacology
Volume103
Issue number2
DOIs
StatePublished - 1991

Fingerprint

Biperiden
Muscarinic Antagonists
Muscarinic Receptors
Procyclidine
Benztropine
Muscarinic M1 Receptors
Radioligand Assay
Scopolamine Hydrobromide
Brain
Pharmacology
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • M and M receptors
  • Parkinsonism drugs
  • Pirenzepine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart. / Larson, E. W.; Pfenning, M. A.; Richelson, E.

In: Psychopharmacology, Vol. 103, No. 2, 1991, p. 162-165.

Research output: Contribution to journalArticle

Larson, E. W. ; Pfenning, M. A. ; Richelson, E. / Selectivity of antimuscarinic compounds for muscarinic receptors of human brain and heart. In: Psychopharmacology. 1991 ; Vol. 103, No. 2. pp. 162-165.
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