Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

Gregory J. Gores; Scott H. Kaufmann

doi:10.1101/gad.186189.111

Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

Gregory J. Gores, Scott H. Kaufmann

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Bcl-2, Bcl-x _L, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-x _L for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120-125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.

Original language	English (US)
Pages (from-to)	305-311
Number of pages	7
Journal	Genes and Development
Volume	26
Issue number	4
DOIs	https://doi.org/10.1101/gad.186189.111
State	Published - Feb 15 2012

Keywords

Acute myeloid leukemia
Apoptosis
Bcl-x
Mcl-1

ASJC Scopus subject areas

General Medicine

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abstract = "Bcl-2, Bcl-x L, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-x L for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120-125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.",

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Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

Abstract

Keywords

ASJC Scopus subject areas

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