Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors

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57 Scopus citations

Abstract

Bcl-2, Bcl-x L, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-x L for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120-125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.

Original languageEnglish (US)
Pages (from-to)305-311
Number of pages7
JournalGenes and Development
Volume26
Issue number4
DOIs
StatePublished - Feb 15 2012

Keywords

  • Acute myeloid leukemia
  • Apoptosis
  • Bcl-x
  • Mcl-1

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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