Selective reactivation of human herpesvirus 6 variant A occurs in critically ill immunocompetent hosts

Raymund R Razonable, C. Fanning, R. A. Brown, M. J. Espy, A. Rivero, J. Wilson, Walter K Kremers, T. F. Smith, C. V. Paya

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Reactivation of human β-herpesviruses (cytomegalovirus [CMV], human herpesvirus [HHV]-6, and HHV-7) in nonimmunocompromised hosts is rare. Because these viruses are susceptible to reactivation by cytokines and stress-related mechanisms, the incidence of their reactivation was investigated among 120 patients during stress related to critical illness and compared with findings among 50 healthy volunteers. Human β-herpesvirus DNA was found in 65% of critically ill patients (60% men; mean age, 63 years) who required admission to an intensive care unit for medical (40%) or surgical (53%) indications or trauma (7%). HHV-6 reactivation was higher in critically ill patients than in healthy volunteers (54/101 vs. 0/50; P = .001). All patients except 1 were confirmed as HHV-6 variant A (mean virus load, 5066 copies/106 peripheral blood leukocytes). The reactivation of HHV-6A did not affect disease severity and outcome. No significant reactivation of HHV-7 or CMV was demonstrated among the critically ill patients. These findings contribute to the less-defined epidemiology of HHV-6A infection.

Original languageEnglish (US)
Pages (from-to)110-113
Number of pages4
JournalJournal of Infectious Diseases
Volume185
Issue number1
DOIs
StatePublished - Jan 1 2002

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Human Herpesvirus 6
Critical Illness
Human Herpesvirus 7
Herpesviridae
Cytomegalovirus
Healthy Volunteers
Viruses
Herpesviridae Infections
Intensive Care Units
Epidemiology
Leukocytes
Cytokines
DNA
Incidence
Wounds and Injuries

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Selective reactivation of human herpesvirus 6 variant A occurs in critically ill immunocompetent hosts. / Razonable, Raymund R; Fanning, C.; Brown, R. A.; Espy, M. J.; Rivero, A.; Wilson, J.; Kremers, Walter K; Smith, T. F.; Paya, C. V.

In: Journal of Infectious Diseases, Vol. 185, No. 1, 01.01.2002, p. 110-113.

Research output: Contribution to journalArticle

Razonable, Raymund R ; Fanning, C. ; Brown, R. A. ; Espy, M. J. ; Rivero, A. ; Wilson, J. ; Kremers, Walter K ; Smith, T. F. ; Paya, C. V. / Selective reactivation of human herpesvirus 6 variant A occurs in critically ill immunocompetent hosts. In: Journal of Infectious Diseases. 2002 ; Vol. 185, No. 1. pp. 110-113.
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