Selective occlusion of vessels using repeated short laser pulses

J. Roider, J. Traccoli, N. Michaud, Thomas J Flotte, R. Anderson, R. Birngruber

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The occlusion of arterioles and venules (30 μm in diameter) by means of repeated dye laser pulses (577 nm, 160 μs, 0.5 Hz) was studied in the hamster cheek pouch model. Microscopically visible changes during and after irradiation were recorded and monitored by a video system. The energy necessary per pulse for vessel occlusion with a single pulse (arterioles 5 J/cm2, venules 3.5 J/cm2) can be lowered more than 50% with 100 pulses (1.8 J/cm2, 1.2 J/cm2). Rupture of vessels, which regularly occurs with a single pulse, can be totally avoided with 100 repetitive laser pulses. Investigations of the temperature dependence of the occlusion rate of arterioles showed different interaction mechanisms with one pulse and 100 pulses (mechanical and thermal respectively). Light and electron microscopic investigations supported this concept of selective occlusion using repeated short laser pulses. Possible clinical applications are portwine stains of the eyelid, neovascularisation on the cornea and subretinal neovascularisation.

Original languageEnglish (US)
Pages (from-to)274-279
Number of pages6
JournalOphthalmologe
Volume91
Issue number3
StatePublished - 1994
Externally publishedYes

Fingerprint

Arterioles
Lasers
Venules
Pulse
Dye Lasers
Cheek
Eyelids
Cricetinae
Cornea
Rupture
Coloring Agents
Hot Temperature
Electrons
Light
Temperature

Keywords

  • dye laser
  • neovascularization
  • occlusion of vessels

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Roider, J., Traccoli, J., Michaud, N., Flotte, T. J., Anderson, R., & Birngruber, R. (1994). Selective occlusion of vessels using repeated short laser pulses. Ophthalmologe, 91(3), 274-279.

Selective occlusion of vessels using repeated short laser pulses. / Roider, J.; Traccoli, J.; Michaud, N.; Flotte, Thomas J; Anderson, R.; Birngruber, R.

In: Ophthalmologe, Vol. 91, No. 3, 1994, p. 274-279.

Research output: Contribution to journalArticle

Roider, J, Traccoli, J, Michaud, N, Flotte, TJ, Anderson, R & Birngruber, R 1994, 'Selective occlusion of vessels using repeated short laser pulses', Ophthalmologe, vol. 91, no. 3, pp. 274-279.
Roider J, Traccoli J, Michaud N, Flotte TJ, Anderson R, Birngruber R. Selective occlusion of vessels using repeated short laser pulses. Ophthalmologe. 1994;91(3):274-279.
Roider, J. ; Traccoli, J. ; Michaud, N. ; Flotte, Thomas J ; Anderson, R. ; Birngruber, R. / Selective occlusion of vessels using repeated short laser pulses. In: Ophthalmologe. 1994 ; Vol. 91, No. 3. pp. 274-279.
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